75-26-3

Basic information

• Product Name: 2-Bromopropane
• Synonyms: Isopropyl bromide;Propane, 2-bromo-
• CAS NO: 75-26-3
• Molecular Formula: C₃H₇Br
• Molecular Weight: 122.99
• EINECS: 200-855-1
• Mol File: 75-26-3.mol
• Article Data: 51

Chemical Properties

• Melting Point: -89℃
• Boiling Point: 60.6 °C at 760 mmHg
• Flash Point: 19.4 °C
• Appearance: Colorless transparent liquid
• Density: 1.342 g/cm³
• Vapor Density: 4.27 (vs air)
• Vapor Pressure: 205mmHg at 25°C
• Refractive Index: 1.429
• Water Solubility: 0.3 g/100 mL
• CAS DataBase Reference: 2-Bromopropane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromopropane(75-26-3)
• EPA Substance Registry System: 2-Bromopropane(75-26-3)

Safety Data

• Hazard Codes: F:Flammable;;
• Statements: R11:; R48/20:; R60:; R66:
• Safety Statements: S16:; S45:; S53:
• PackingGroup: II
• Hazardous Substances Data: 75-26-3(Hazardous Substances Data)

Usage

General Description

2-Bromopropane, also known as isopropyl bromide, is a colorless liquid with a faint odor. It is a halogenated hydrocarbon that is used primarily as a solvent in various chemical reactions and processes. It is highly flammable and can also act as a starting material for the production of other chemicals. 2-Bromopropane is also used in the manufacturing of pharmaceuticals, pesticides, and as a cleaning agent in the electronics industry. It is important to handle this chemical with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system. Additionally, prolonged exposure to this chemical can have harmful effects on the central nervous system and reproductive organs.

InChI:InChI=1/C3H7Br/c1-3(2)4/h3H,1-2H3

Synthetic route

propene (187737-37-7) → propyl bromide (106-94-5) + isopropyl bromide (75-26-3)

Conditions	Yield
With hydrogen bromide; oxygen at 20 - 23℃; under 1551.49 - 1603.2 Torr; for 4.5h;	A 97.8% B 1.57%

propane (74-98-6) → isopropyl bromide (75-26-3)

Conditions	Yield
With 2AlBr3*CBr4; bromine at -20℃; for 3h;	96%
With antimony pentafluoride; 1,2-dibromomethane 1.) -78 deg C, 2 h, 2.) RT, 24 h;	64%
With 2AlBr3*CBr4; bromine In various solvent(s) at -20℃; for 3h;	48 % Turnov.

isopropyl alcohol (67-63-0) → isopropyl bromide (75-26-3)

Conditions	Yield
With carbon tetrabromide; sodium bromide In N,N-dimethyl-formamide for 3h; Catalytic behavior; Irradiation;	93%
With tetralin; bromine ueber mehrere Stufen;
With sulfuric acid; potassium bromide

triisopropyl phosphite (116-17-6) + para-bromoacetophenone (99-90-1) → diisopropyl [4-(acetyl)phenyl]phosphonate (106052-23-7) + isopropyl bromide (75-26-3)

Conditions	Yield
With nickel dichloride at 180 - 190℃; for 0.0833333h;	A 91% B n/a

di-isopropyl ether (108-20-3) + carbon monoxide (201230-82-2) + 4-Methylbenzyl bromide (104-81-4) → isopropyl 2-p-tolylacetate (64450-64-2) + isopropyl bromide (75-26-3)

Conditions	Yield
1,5-hexadienerhodium(I)-chloride dimer; potassium iodide at 75 - 90℃; under 735.5 Torr; overnight or in n-heptane;	A 78% B n/a

{(η5-C5Me5)Os(CO)(PMe2Ph)i-Pr} (116670-01-0) + bromine (7726-95-6) → {(η5-C5Me5)Os(CO)(PMe2Ph)Br} (107087-80-9) + propene (187737-37-7) + isopropyl bromide (75-26-3)

Conditions	Yield
In dichloromethane-d2 (N2); electrophilic cleavage reaction by addn. of bromine to a soln. of Cp*Os(CO)(PMe2Ph)i-Pr in CD2Cl2;; not isolated, detected by NMR;;	A 77% B 9% C 50%

{(η5-C5Me5)Os(CO)2i-Pr} (116669-98-8) + mercury dibromide → {(η5-C5Me5)Os(CO)2Br} (81554-89-4) + isopropylmercury (1+); bromide (18819-83-5) + isopropyl bromide (75-26-3)

Conditions	Yield
In dichloromethane-d2 (N2); electrophilic cleavage reaction by addn. of HgBr2 to a soln. of Cp*Os(CO)2i-Pr in CD2Cl2;; not isolated, detected by NMR;;	A 77% B 61% C 11%

triisopropyl phosphite (116-17-6) + 1-(3-Bromophenyl)ethanone (2142-63-4) → (3-Acetyl-phenyl)-phosphonic acid diisopropyl ester (127099-70-1) + isopropyl bromide (75-26-3)

Conditions	Yield
With nickel dichloride at 180 - 190℃; for 0.0833333h;	A 76% B n/a

{(η5-C5Me5)Os(CO)2i-Pr} (116669-98-8) + bromine (7726-95-6) → {(η5-C5Me5)Os(CO)2Br} (81554-89-4) + propene (187737-37-7) + isopropyl bromide (75-26-3)

Conditions	Yield
In dichloromethane-d2 (N2); electrophilic cleavage reaction by addn. of bromine to a soln. of Cp*Os(CO)2i-Pr in CD2Cl2;; not isolated, detected by NMR;;	A 75% B 6% C 39%

2-isopropyl-2-boraadamantane (76313-88-7) → 2-bromo-2-boraadamantane (76313-91-2) + 3α-bromo-7α-[(2-propyl)bromoboryl]bicyclo[3.3.1]nonane + 4-ethoxy-5,5-dimethyl-4-borahomoadamantane + hydrogen bromide (10035-10-6, 12258-64-9) + isopropyl bromide (75-26-3)

Conditions	Yield
With ethanol; bromine In dichloromethane Irradiation (UV/VIS); under Ar, to soln. of educt in CH2Cl2 added soln. of Br2 in CH2Cl2 in portions during 1 h at -10°C under pressure of 170-200 mmHg with irrdn. with 200 W bulb, stirred for 30 min at -10°C, heated under vac. to 17°C; concd. in vac., cooled to -70°C, ethanol added, evapd. in vac. without heating; GLC anal. of products after oxidative hydrolysis;	A n/a B n/a C n/a D 73% E 4%
With ethanol; bromine In dichloromethane under Ar in the dark, to soln. of educt in CH2Cl2 added soln. of Br2 inCH2Cl2 in portions during 5.5 h at -10°C under pressure of 170-200 mmHg, stirred for 30 min at -10°C, heated under vac. to 17°C; concd. in vac., cooled to -70°C, ethanol added, evapd. in vac. without heating; GLC anal. of products after oxidative hydrolysis;	A n/a B n/a C n/a D 14% E 65%
With ethanol; bromine In dichloromethane under Ar, to soln. of educt in CH2Cl2 added soln. of Br2 in CH2Cl2 in portions during 2.5 h at -10°C under pressure of 170-200 mmHg, stirred for 30 min at -10°C, heated under vac. to 17°C; concd. in vac., cooled to -70°C, ethanol added, evapd. in vac. without heating; GLC anal. of products after oxidative hydrolysis;	A n/a B n/a C n/a D 23% E 38%

triisopropyl phosphite (116-17-6) + 1,3-chlorobromopropane (109-70-6) → O,O-diisopropyl (3-chloropropyl)phosphonate (63602-20-0) + isopropyl bromide (75-26-3)

Conditions	Yield
at 135 - 140℃; for 3h; Arbuzov rearrangement;	A 28% B 68%

1-bromo-4-methoxy-benzene (104-92-7) + triisopropyl phosphite (116-17-6) → diisopropyl (4-methoxyphenyl)phosphonate (106052-22-6) + isopropyl bromide (75-26-3)

Conditions	Yield
With nickel dichloride at 185 - 195℃; for 0.0833333h;	A 67% B n/a

bromobenzene (108-86-1) + triisopropyl phosphite (116-17-6) → diisopropyl phenylphosphonate (7237-16-3) + isopropyl bromide (75-26-3)

Conditions	Yield
With nickel dichloride at 185 - 195℃; for 0.0833333h;	A 65.5% B n/a

diethyl phenylphosphonite (1638-86-4) + 1,3-chlorobromopropane (109-70-6) → isopropyl bromide (75-26-3) + ethyl (3-chloropropyl)phenylphosphinate (231610-93-8)

Conditions	Yield
at 135 - 140℃; for 3h; Arbuzov rearrangement;	A n/a B 62%

triisopropyl phosphite (116-17-6) + 2-bromoanisole (578-57-4) → (2-Methoxy-phenyl)-phosphonic acid diisopropyl ester (127099-69-8) + isopropyl bromide (75-26-3)

Conditions	Yield
With nickel dichloride at 190 - 200℃; for 0.0833333h;	A 61% B n/a
nickel dichloride at 190 - 200℃;

triisopropyl phosphite (116-17-6) + 4-bromo-benzaldehyde (1122-91-4) → 4-(diisopropoxyphosphoryl)benzaldehyde (127099-71-2) + isopropyl bromide (75-26-3)

Conditions	Yield
With nickel dichloride at 170 - 180℃; for 0.0833333h;	A 54% B n/a

propyl bromide (106-94-5) → isopropyl bromide (75-26-3)

Conditions	Yield
at 250 - 270℃; Equilibrium constant;
at 250 - 270℃; Equilibrium constant; die Umlagerung wird durch Sauerstoff, HBr, HgBr2, Tetraaethylammoniumbromid und Dibutylamin beschleunigt;
lagert sich im UV-Licht teilweise um;

2-iodo-propane (75-30-9) → isopropyl bromide (75-26-3)

Conditions	Yield
With bromine
With hydrogen bromide
With pyridine; tributyltin bromide at 125℃; Thermodynamic data; Equilibrium constant; Δ G;	49 % Chromat.

propene (187737-37-7) → isopropyl bromide (75-26-3)

Conditions	Yield
With hydrogen bromide bei Ausschluss von Luft und Zusatz von Oxydationsverzoegern wie Diphenylamin oder Thiokresol;
With tetrachloromethane; hydrogen bromide
With hydrogen bromide; iron(III) chloride im Dunkeln;

1,2-Dibromopropane (78-75-1) → isopropyl bromide (75-26-3)

Conditions	Yield
With hydrogen iodide at 150℃;

propane (74-98-6) → 1,2-Dibromopropane (78-75-1) + propyl bromide (106-94-5) + 1,3-dibromo-propane (109-64-8) + isopropyl bromide (75-26-3)

Conditions	Yield
at 300 - 330℃; Bromierung; weitere Produkte: 2.2-Dibrom-propan, Tribrompropan und Tetrabrompropan;

propane (74-98-6) → propyl bromide (106-94-5) + isopropyl bromide (75-26-3)

Conditions	Yield
With bromine at 300 - 330℃;
With Bromoform; 1,2-dibromomethane In nitrogen at 525℃; for 0.0166667h;

bromo-triphenyl-methane (596-43-0) + isopropyl-diphenyl-phosphine oxide (2959-75-3) → diphenyl-trityl-phosphine oxide + isopropyl bromide (75-26-3)

Conditions	Yield
at 100 - 200℃;

bromo-triphenyl-methane (596-43-0) + isopropyl diphenylphosphinite (27350-46-5) → diphenyl-trityl-phosphine oxide + isopropyl bromide (75-26-3)

Conditions	Yield
at 100 - 200℃;

isopropyl alcohol (67-63-0) → 1,1,1-tribromopropan-2-one (3770-98-7) + isopropyl bromide (75-26-3)

Conditions	Yield
With bromine

toluene-4-sulfonic acid isopropyl ester (2307-69-9) → isopropyl bromide (75-26-3)

Conditions	Yield
With tetrabutylammomium bromide In acetone at 50℃; Kinetics; other reaction partners, other solvents, other temperatures;

isopropyl radical (2025-55-0) → isopropyl bromide (75-26-3)

Conditions	Yield
With bromine at 24.9℃; Kinetics; other temperatures;

propene (187737-37-7) → 2-bromo-2-methylpentane (4283-80-1) + propyl bromide (106-94-5) + isopropyl bromide (75-26-3)

Conditions	Yield
With hydrogen bromide at -78℃; for 96h; Product distribution;	A 34 % Chromat. B 0.5 % Chromat. C 45 % Chromat.
With hydrogen bromide at -78℃; for 96h;	A 34 % Chromat. B 0.5 % Chromat. C 45 % Chromat.

isopropyl chloride (75-29-6) → isopropyl bromide (75-26-3)

Conditions	Yield
With tributyltin bromide In pyridine at 50℃; Thermodynamic data; Equilibrium constant; other temperatures, Δ G;

meta-hydroxybenzaldehyde (100-83-4) + isopropyl bromide (75-26-3) → 3-isopropoxybenzaldehyde (75792-33-5)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	100%
With potassium carbonate In N,N-dimethyl-formamide at 70℃;	90%
In acetone	88%

isovanillin (621-59-0) + isopropyl bromide (75-26-3) → O-isopropylisovanillin (34123-66-5)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;	100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	100%
With potassium carbonate In dimethyl sulfoxide at 55℃; for 11h; Inert atmosphere;	100%

4-Bromophenylacetonitrile (16532-79-9) + isopropyl bromide (75-26-3) → 2-(4-bromophenyl)-3-methylbutanenitrile (51632-12-3)

Conditions	Yield
Stage #1: 4-Bromophenylacetonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; Inert atmosphere; Stage #2: isopropyl bromide In N,N-dimethyl-formamide; mineral oil for 16h; Inert atmosphere; Heating;	100%
Stage #1: 4-Bromophenylacetonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.25h; Stage #2: isopropyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;
Stage #1: 4-Bromophenylacetonitrile With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.25h; Stage #2: isopropyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h;	21.3 g
Stage #1: 4-Bromophenylacetonitrile With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: isopropyl bromide In tetrahydrofuran for 16h; Inert atmosphere;
With sodium hydride

vanillin (121-33-5) + isopropyl bromide (75-26-3) → 4-isopropyloxy-3-methoxybenzaldehyde (2538-98-9)

Conditions	Yield
	100%
With potassium carbonate In N,N-dimethyl-formamide at 18℃; for 19h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	100%

diphenyl diselenide (1666-13-3) + isopropyl bromide (75-26-3) → (phenylseleno)-2-propane (22233-89-2)

Conditions	Yield
With sodium tetrahydroborate In 1,2-dimethoxyethane at 20℃; for 12h; Inert atmosphere;	100%
With indium iodide In dichloromethane at 20℃; for 1h;	80%
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran for 3h; Heating;	78%
With triphenylphosphine; 1-pentyl-3-methylimidazolium bromide at 75℃; for 6h;	72%

6-hydroxy-7-methoxy-1-tetralone (15288-02-5) + isopropyl bromide (75-26-3) → 6-isopropoxy-7-methoxy-1-tetralone (98799-45-2)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide Heating;	100%

sodium 4-methylbenzenesulfonothioate (3753-27-3) + isopropyl bromide (75-26-3) → 4-Methylbenzolthiosulfonsaeure-S-isopropylester (53291-31-9)

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	100%
With Amberlyst A-26 (Cl(1-) form) 1.) H2O, r.t., 18 h; 2.) benzene, reflux, 25 h; Yield given. Multistep reaction;

isopropyl bromide (75-26-3) + phenylphosphane (638-21-1) → isopropyl(phenyl)phosphine (54722-12-2)

Conditions	Yield
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran at 65℃; for 6h;	100%
With potassium hydroxide 1.) DMSO, 2.) 50 - 60 deg C, 1 h; Yield given. Multistep reaction;
With potassium hydroxide 1) DMSO, 20 deg C, 2) DMSO, 50-60 deg C, 1.0 h; Yield given. Multistep reaction;

(E)-3-phenylpropenal (14371-10-9) + phenyllithium (591-51-5) + isopropyl bromide (75-26-3) → (+/-)-4-methyl-1,3-diphenylpentan-1-one (85267-90-9)

Conditions	Yield
Stage #1: (E)-3-phenylpropenal; phenyllithium In tetrahydrofuran at 20℃; for 7h; Stage #2: isopropyl bromide In tetrahydrofuran Further stages.;	100%
Stage #1: (E)-3-phenylpropenal; phenyllithium In tetrahydrofuran at 20℃; for 7h; Addition; Stage #2: isopropyl bromide In tetrahydrofuran at 20℃; Alkylation;	100 % Chromat.

isopropyl bromide (75-26-3) + ethanethiol (75-08-1) → ethyl isopropyl sulfide (5145-99-3)

Conditions	Yield
Stage #1: ethanethiol With sodium tetrahydroborate; sodium hydroxide In water at 5℃; Inert atmosphere; Stage #2: isopropyl bromide; tetrabutylammomium bromide In water at 50℃; Inert atmosphere;	100%
With potassium hydroxide In ethanol for 0.5h; Heating;	51%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + isopropyl bromide (75-26-3) → 2-isopropoxy-3-methoxy-benzaldehyde (75792-35-7)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃; Industry scale; Inert atmosphere;	100%
With potassium carbonate In N,N-dimethyl-formamide at 110℃;	99%
Stage #1: 3-methoxy-2-hydroxybenzaldehyde With tetrabutylammomium bromide; potassium carbonate In acetone at 20℃; for 0.25h; Stage #2: isopropyl bromide In acetone at 20℃; for 24h;	96%

6-Pentadecylsalicylic Acid (16611-84-0) + isopropyl bromide (75-26-3) → isopropyl-2-isopropoxy-6-pentadecylbenzoate (440094-90-6)

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In 4-methyl-2-pentanone for 24h; Reflux;	100%
With potassium carbonate In various solvent(s) for 36h; Heating;
With benzyltri(n-butyl)ammonium chloride; potassium carbonate In 4-methyl-2-pentanone for 8h; Heating / reflux;
With benzyltri(n-butyl)ammonium chloride; potassium carbonate In 4-methyl-2-pentanone for 8h; Heating / reflux;

3-phenylsalicylic acid (304-06-3) + isopropyl bromide (75-26-3) → 2-isopropoxy-biphenyl-3-carboxylic acid isopropyl ester (566162-84-3)

Conditions	Yield
With potassium carbonate at 50℃; for 12h;	100%

o-hydroxyacetophenone (118-93-4) + isopropyl bromide (75-26-3) → 1-(2-(1-methylethoxy)phenyl)ethanone (70201-54-6)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 3h; Inert atmosphere;	100%
With potassium carbonate In N,N-dimethyl-formamide at 70℃;	94%
With potassium carbonate; potassium iodide In acetone Heating;	91%

isopropyl bromide (75-26-3) + 2,3-dimercaptobenzoic acid methyl ester (178626-86-3) → 2,3-bis-isopropylsulfanyl-benzoic acid methyl ester (547765-68-4)

Conditions	Yield
With lithium methanolate In methanol for 20h; Heating;	100%

4-bromoguaiacol (7368-78-7) + isopropyl bromide (75-26-3) → 4-bromo-1-isopropoxy-2-methoxy-benzene (138505-27-8)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 90℃;	100%
With potassium carbonate In dimethyl sulfoxide at 20 - 55℃; for 2h;	94%
With potassium carbonate In dimethyl sulfoxide at 55℃; for 2h;	84%

ethyl 5-bromo-4-hydroxy-3-methylbenzofuran-2-carboxylate (73751-11-8) + isopropyl bromide (75-26-3) → ethyl 5-bromo-4-isopropoxy-3-methyl-1-benzofuran-2-carboxylate (857081-69-7)

Conditions	Yield
With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 20℃; for 12h;	100%

5-bromo-4-hydroxy-3-methoxybenzaldehyde (2973-76-4) + isopropyl bromide (75-26-3) → 3-bromo-4-isopropyloxy-5-methoxybenzaldehyde (400070-31-7)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	100%

2,2'-dihydroxybiphenyl-3,3'-dicarboxylic acid bisdiethyl amide (898830-67-6) + isopropyl bromide (75-26-3) → 2,2'-diisopropoxy-biphenyl-3,3'-dicarboxylic acid bis-diethylamide (898830-75-6)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide	100%

methyl 4-hydroxylbenzoate (99-76-3) + isopropyl bromide (75-26-3) → methyl 4-isopropoxybenzoate (35826-59-6)

Conditions	Yield
With potassium carbonate In acetone for 72h; Inert atmosphere; Reflux;	100%
With potassium carbonate In acetone for 72h; Inert atmosphere; Reflux;	100%
With potassium carbonate In acetone at 85℃; for 72h; Sealed tube;	94.7%
With sodium hydride In N,N-dimethyl-formamide at 60℃;	80%

5,6-dihydroxy-indan-1-one (124702-80-3) + isopropyl bromide (75-26-3) → 5,6-diisopropoxyindan-1-one (760995-28-6)

Conditions	Yield
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 60℃; for 8h;	100%

5-hydroxy-2,3-dihydro-1H-indene-1-one (3470-49-3) + isopropyl bromide (75-26-3) → 5-isopropoxyindan-1-one (760995-38-8)

Conditions	Yield
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 60℃;	100%

methyl 4-hydroxybenzofuran-2-carboxylate (127724-13-4) + isopropyl bromide (75-26-3) → methyl 4-isopropoxy-1-benzofuran-2-carboxylate (857080-64-9)

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃;	100%

5-chloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (99246-81-8) + isopropyl bromide (75-26-3) → 5-chloro-4-isopropoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (857080-97-8)

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃;	100%

2-(3,5-dichloro-2-hydroxy-benzenesulfonylamino)-indan-2-carboxylic acid ethyl ester (1092447-34-1) + isopropyl bromide (75-26-3) → 2-(3,5-dichloro-2-isopropoxy-benzenesulfonylamino)-indan-2-carboxylic acid ethyl ester (1092447-35-2)

Conditions	Yield
With caesium carbonate; potassium iodide In N,N-dimethyl-formamide at 110℃; for 2.5h; Microwave irradiation;	100%

6-bromo-pyridin-3-ol (55717-45-8) + isopropyl bromide (75-26-3) → 2-bromo-5-isopropoxypyridine (857992-23-5)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;

5-amino-2-chlorophenol (6358-06-1) + isopropyl bromide (75-26-3) → 4-chloro-3-isopropoxyaniline (76464-54-5)

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;	100%
With potassium carbonate In acetonitrile at 20℃; for 24h; Reflux;	87%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 2.5h;	58%
With potassium carbonate In acetonitrile at 80℃; for 16h;	47%

1-vinylimidazole (1072-63-5) + isopropyl bromide (75-26-3) → 1-vinyl-3-isopropylimidazolium bromide (1020109-60-7)

Conditions	Yield
for 16h; Reflux;	100%

2-(4-bromo-phenyl)-5-hydroxy-benzofuran-3-carboxylic acid ethyl ester (5010-37-7) + isopropyl bromide (75-26-3) → ethyl 2-(4-bromophenyl)-5-isopropoxybenzofuran-3-carboxylate (691856-79-8)

Conditions	Yield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 60℃; for 4h;	100%
Stage #1: 2-(4-bromo-phenyl)-5-hydroxy-benzofuran-3-carboxylic acid ethyl ester With caesium carbonate In 1-methyl-pyrrolidin-2-one at 20℃; for 0.333333h; Stage #2: isopropyl bromide In 1-methyl-pyrrolidin-2-one at 80℃; for 4h;	95%

3-Bromothiophenol (6320-01-0) + isopropyl bromide (75-26-3) → 1-bromo-3-isopropylsulfanylbenzene (70398-87-7)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	100%
With potassium carbonate In acetonitrile for 2h; Reflux;	72%
With potassium carbonate In acetone for 18h; Inert atmosphere; Reflux;

Upstream product

• 187737-37-7 propene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 116-17-6 triisopropyl phosphite 
• 99-90-1 para-bromoacetophenone 
• 7727-15-3 aluminium bromide 
• 106-94-5 propyl bromide 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 67-63-0 isopropyl alcohol 
• 7446-70-0 aluminium trichloride 
• 74-98-6 propane 
• 10034-85-2 hydrogen iodide 
• 7553-56-2 iodine 
• 106-95-6 allyl bromide 

Downstream Products

• 4318-42-7 1-(1-methylethyl)piperazine 
• 57707-13-8 2-isopropyl-2H-indazole 
• 817166-87-3 2-isopropylmercapto-4-methyl-quinoline 
• 109500-34-7 4-isopropylamino-1,2-dimethyl-5-phenyl-1,2-dihydro-pyrazol-3-one 
• 6299-06-5 8-isopropylmercapto-1,3,9-trimethyl-3,9-dihydro-purine-2,6-dione 
• 5558-29-2 3-methyl-2-phenyl-butyronitrile 
• 22921-58-0 2-isopropoxybenzaldehyde 
• 109-56-8 i-propyl(2-(hydroxy)ethyl)amine 
• 19177-04-9 1-isopropoxy-3-methylbenzene 
• 3711-34-0 N,N'-diisopropylhydrazine 
• 921-14-2 N,N-diisopropylhydrazine 
• 63370-00-3 3-Methyl-2-phenylbutansaeure-ethylester 
• 109961-79-7 4-[2-(N-acetyl-sulfanilyl)-ethyl]-1-isopropyl-pyridinium; bromide 
• 3615-24-5 ramifenazone 

Relevant articles and documents

Synthesis, characterization, crystal structure, and antimicrobial studies of 2-morpholinoethyl-substituted benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes

This article describes synthesis of N-morpholinoethylbenzimidazole (1), 2-morpholinoethyl-substituted benzimidazolium salts (NHC precursors, 2a–c), and their Ag(I) N-heterocyclic carbene (NHC) complexes (3a–c). All compounds were characterized by 1H and 13C Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared Spectroscopy (FTIR), and elemental analysis, and their antimicrobial effects examined. The molecular structure of the NHC precursor 2a1 was established by single-crystal X-ray diffraction analysis. Minimum Inhibition Concentration (MIC) values were determined to evaluate their antimicrobial activity against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacterial strains and Candida albicans fungal species. All tested samples were compared with silver nitrate. All the compounds exhibited strong antimicrobial activity.

Sulfonyl halide synthesis by thiol oxyhalogenation using NBS/NCS – iPrOH

A rapid and facile method provides a general route to sulfonyl bromides/chlorides by the oxidation of thiols using NXS – ROH (X?=?Br,Cl, R?=?iPr) as an oxyhalogenation reagent. Control experiments suggest that the alcohol component is the source of oxygen. The proposed method enable the access to structurally diverse sulfonyl bromides and chlorides including challenging examples, inaccessible by other synthetic methods.

Ruthenium bipyridyl tethered porous organosilica: A versatile, durable and reusable heterogeneous photocatalyst

A versatile heterogeneous photocatalysis protocol was developed by using ruthenium bipyridyl tethered porous organosilica (Ru-POS). The versatility of the Ru-POS catalyst in organo-photocatalysis was explored by (i) oxidative aromatization of Hantzsch ester, (ii) reductive dehalogenation of alkyl halides, and (iii) functional group interconversion (FGI) of alcohols to alkyl halides. This journal is