- Direct Synthesis of Lactams from Keto Acids, Nitriles, and H2 by Heterogeneous Pt Catalysts
-
We report herein the first general catalytic system for the direct synthesis of N-substituted γ- and δ-lactams by reductive amination/cyclization of keto acids (including levulinic acid) with nitriles and H2 under mild conditions (7 bar H2, 110 °C, solvent free). The most effective catalyst, Pt and MoOx co-loaded TiO2 (Pt-MoOx/TiO2), shows a wide substrate scope, high turnover number (TON), and good reusability.
- Siddiki,Touchy, Abeda S.,Bhosale, Ashvini,Toyao, Takashi,Mahara, Yuji,Ohyama, Junya,Satsuma, Atsushi,Shimizu, Ken-Ichi
-
p. 789 - 795
(2018/02/27)
-
- Cyclic sulfamidates as vehicles for the synthesis of substituted lactams
-
(Chemical Equation Presented) A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and α-fu
- Bower, John F.,Svenda, Jakub,Williams, Andrew J.,Charmant, Jonathan P. H.,Lawrence, Ron M.,Szeto, Peter,Gallagher, Timothy
-
p. 4727 - 4730
(2007/10/03)
-
- ELECTROPHILIC OLEFIN HETEROCYCLIZATION IN ORGANIC SYNTHESIS. FORMATION OF δ-LACTAMS BY IODINE-INDUCED LACTAMIZATION OF δ,ε-UNSATURATED THIOIMIDATES
-
The diastereoselective iodine-induced lactamization of δ,ε-unsaturated thioimidates (1) accessible from allylation of a dianion of N-benzyl-3-phenylsulfonylpropionamide (3) followed by elaboration gave the substituted δ-lactams (2).
- Takahata, Hiroki,Wang, Eng-Chi,Ikuro, Kazumi,Yamazaki, Takao,Momose, Takefumi
-
p. 435 - 440
(2007/10/02)
-