- Selective sodium channel regulator as well as preparation and application thereof
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The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.
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- 2-amino-X-nitrobenzimidazoles as precursors of food-borne carcinogens: A new approach to IQ synthesis
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Cyclization of (non)-methylated nitro-o-phenylenediamines with cyanogen bromide provided nitro-substituted 2-aminobenzimidazoles in good up to excellent yields. Catalytic hydrogenation of 2-amino-1-methyl-5-nitrobenzimidazole yielded 2,5-diamino-1-methylbenzimidazole, which on treatment with 1,1,3,3-tetramethoxypropane in methanol and subsequently after removal of methanol in polyphosphoric acid afforded food-borne carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in 20% yield. Copyright
- Bella, Maros,Milata, Viktor,Larina, Lyudmila I.
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experimental part
p. 293 - 296
(2012/06/04)
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- Vicarious nucleophilic C-amination of nitrobenzene and 5- and 6-nitro-1-methylbenzimidazoles
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Vicarious nucleophilic C-amination of nitrobenzene, 1-methyl-5- nitrobenzimidazole, and 1-methyl-6-nitrobenzimidazole in superbasic medium (potassium tert-butoxide-dimethyl sulfoxide) gave the corresponding amino-substituted derivatives. The yield of the
- Titova,Vakul'skaya,Larina,Mizandrontsev,Volkov,Dolgushin,Lopyrev
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p. 1306 - 1315
(2007/10/03)
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