506-68-3Relevant articles and documents
Kinetics and Mechanism of the Br2-HCN Reaction
Valent, Ivan,Adamcikova, Lubica
, p. 7939 - 7941 (1993)
The reaction between bromine and cyanide in aqueous acid solution (HClO4) has been studied at 25 deg C using a conventional spectrophotometric method.Under conditions of an excess of CN(1-), H(1+), and Br(1-) ions the experimental kinetic law has the form -d/dt = (a + b + c)/(1 + d, where a = 7.5 +/- 1 s-1, b = 45 +/- 10 M-1 s-1, c = 48 +/- 4 M-1 s-1, and d = 12 +/- 4 M-1.The results are consistent with a mechanism involving steps Br2 + CN(1-) -> BrCN + Br(1-) with rate constant k1 = (6.7 +/- 0.9) x 109 M-1 s-1, Br3(1-) + CN(1-) -> BrCN + 2Br(1-) with k2 = (2.4 +/- 0.6) x 109 M-1 s-1, and Br2 + HCN -> BrCN + Br(1-) + H(1+) with k3 = 48 +/- 4 M-1 s-1.A nonlinear regression method was successfully used in analysis of the experimental data.
Designing chiral amido-oxazolines as new chelating ligands devoted to direct Cu-catalyzed oxidation of allylic C–H bonds in cyclic olefins
Samadi, Saadi,Jadidi, Khosrow,Samadi, Mojgan,Ashouri, Akram,Notash, Behrouz
supporting information, p. 862 - 867 (2019/01/08)
A new type of amido-oxazoline ligands was conveniently synthesized from inexpensive and commercially available materials in high yields and enantiomeric excesses. The corresponding chiral copper complexes with this class of ligands [C2 symmetric S,S-bis(amido-oxazoline-Cu(II) complex] were synthesized accordingly. The ORTEP diagram of ligand 6a and complex 6a-copper were compared and characterization of the complex confirmed the involvement of both dentate parts of the ligands, the oxygen and nitrogen atoms, in complexation with copper. The utilization of this amido-oxazoline ligands in the copper-catalyzed enantioselective esterification of allylic C–H bonds of cyclic olefins with tert-butyl-4-nitrobenzoperoxoate resulted in the highest activities, yields (up to 95%) and enantioselectivities (up to 96%) in the presence of HZSM-5 zeolite. These new findings highlight the protocol as one of the most attractive and useful methods for the oxidation of the asymmetric allylic C–H bond of cycloalkenes compared to other methodologies reported in the literature.
Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines
Glotz, Gabriel,Lebl, René,Dallinger, Doris,Kappe, C. Oliver
supporting information, p. 13786 - 13789 (2017/10/09)
A continuous-flow process for the in situ on-demand generation of cyanogen bromide (BrCN) from bromine and potassium cyanide that makes use of membrane-separation technology is described. In order to circumvent the handling, storage, and transportation of elemental bromine, a continuous bromine generator using bromate–bromide synproportionation can optionally be attached upstream. Monitoring and quantification of BrCN generation was enabled through the implementation of in-line FTIR technology. With the Br2 and BrCN generators connected in series, 0.2 mmol BrCN per minute was produced, which corresponds to a 0.8 m solution of BrCN in dichloromethane. The modular Br2/BrCN generator was employed for the synthesis of a diverse set of biologically relevant five- and six-membered cyclic amidines and guanidines. The set-up can either be operated in a fully integrated continuous format or, where reactive crystallization is beneficial, in semi-batch mode.
Process for Preparing High Purity Dicyclopentadiene-phenol Type Cyanate Compounds
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Paragraph 0029-0031, (2016/12/26)
The present invention refers to brominated cyanide (Cyanogen bromide) and phenol en- claw pen hit D between D (Dicyclopentadiene-phenol) compound formed by manufacturing method relates to cyanate ester compounds, said compounds are isopropyl alcohol (IPA), water, methyl ethyl ketone (MEK) by a cleaning process for the oxide layer produced cyanate ester compound purity recent printed circuit board (PCB) and copper-clad laminate (CCL) from a microelectronic substrate such as required of high-thermal resistance, low dielectric, a low hygroscopicity in exhibits excellent performance.
METHOD FOR PRODUCING CYANOGEN-HALIDE, CYANATE ESTER COMPOUND AND METHOD FOR PRODUCING THE SAME, AND RESIN COMPOSITION
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Paragraph 0277, (2015/12/09)
A method for efficiently producing a cyanogen halide with suppressed side effects, and a method for producing a high-purity cyanate ester compound at a high yield includes contacting a halogen molecule with an aqueous solution containing hydrogen cyanide and/or a metal cyanide, so that the hydrogen cyanide and/or the metal cyanide is allowed to react with the halogen molecule in the reaction solution to obtain the cyanogen halide, wherein more than 1 mole of the hydrogen cyanide or the metal cyanide is used based on 1 mole of the halogen molecule, and when an amount of substance of an unreacted hydrogen cyanide or an unreacted metal cyanide is defined as mole (A) and an amount of substance of the generated cyanogen halide is defined as mole (B), the reaction is terminated in a state in which (A):(A)+(B) is between 0.00009:1 and 0.2:1.
HALOGEN-ALKYL-1,3 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS
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Page/Page column, (2014/04/03)
The present invention provides compounds of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
Non-Nucleoside reverse transcriptase inhibitors
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Page/Page column 16, (2009/01/23)
Compounds of formula I, wherein R1, R2, R3, X and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
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Page/Page column 36, (2009/01/20)
Compounds of formula (I), wherein R1, X1, X2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula (I) useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
Cathepsin cysteine protease inhibitors
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Page 8, (2010/02/06)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
Reaction of AgOCN with NO, NO2, CINO2, CINO, and BrNO: Evidence of the Formation of OCN-NO2 and OCN-NO
Klapo?tke, Thomas M.,Schulz, Axel
, p. 7897 - 7904 (2008/10/09)
Reactions of silver cyanate with binary nitrogen oxides, NO and NO2, and ternary nitrogen oxohalides, C1NO2, C1NO, and BrNO, were studied by means of gas phase IR spectroscopy. The experimental data for the neat reactions of AgOCN with NO2 and AgOCN with C1NO2 are compatible with the formation of an intermediate, short-lived OCN-NO2 molecule, which undergoes cleavage-rearrangement to give N2O and CO2. In contrast, NO does not react with AgOCN. The reaction of XNO (X = Cl, Br) and AgOCN is much more complex, leading to a mixture of NO, NO2, N2O, CO2, NCNCO, and X(CO)NCO. A reaction mechanism that involves the formation of neutral nitrosyl isocyanate, OCN-NO, has been proposed as the initial step. The two neutral intermediates, OCN-NO2 and OCN-NO, were computed by ab initio methods at the correlated MP2 level of theory and are discussed in terms of intramolecular stabilization by donor-acceptor interaction (negative hyperconjugation).
