cas 56030-54-7, Sufentanil | Articles data

Articles about 56030-54-7Total 9 be found

Preparation method of alfentanil and sufentan and compounds used for preparation of sufentanil and alfentan
The invention discloses a preparation method of alfentanil and sufentan and compounds used for preparation of sufentanil and alfentan. Specifically, the method for preparation of a compound shown as formula V includes: carrying out BOC reaction on a compound shown as formula IV to obtain the compound shown as formula V in the specification. The method can conveniently, efficiently and safely prepare an intermediate product for synthesis of alfentanil and sufentan, i.e. the compound shown as formula V. And then, the compound shown as formula V can be effectively used for preparation of alfentanil and sufentan.
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(2017/06/02)

PREPARATION OF SUFENTANIL CITRATE AND SUFENTANIL BASE
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
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Paragraph 0114

(2016/12/16)

Process for the Preparation of Sufentanil Base and Related Compounds
The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which
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Page/Page column 8

(2012/04/04)

IMPROVED METHOD OF MAKING PIPERIDINE DERIVATIVES
The present invention relates to a process for the preparation of piperidine derivatives including sufentanil, and their pharmaceutically acceptable salts, such as the citrate salt.
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Page/Page column 15-16

(2010/06/11)

SUBSTITUTED 4-AMINO-PIPERIDINES
The present invention relates to new substituted 4-amino-piperidine opioid receptor modulators, pharmaceutical compositions thereof, and methods of use thereof
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Page/Page column 26-27

(2010/02/17)

A facile method for preparation of [2H3]-sufentanil and its metabolites
An improved process for the synthesis of sufentanil with an overall yield of 26% is described. The reactive and high yielding N-debenzylation of the piperidine intermediate 7 using a mixture of Pd/C and Pd(OH)2 was applied to other drug intermediates affording free amines in short reaction times. The deuterium-labeled sufentanil and the metabolite desmethylsufentanil were synthesized applying the optimized process.
Srimurugan, Sankareswaran,Murugan, Kaliyappan,Chen, Chinpiao
experimental part
p. 1421 - 1424
(2010/06/14)

IMPROVED METHOD OF MAKING SUFENTANIL
The present invention relates to a process for the preparation of piperidine derivatives including sufentanil and its pharmaceutically acceptable salts, such as it citrate salt
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Page/Page column 4; 11

(2010/11/29)

Methods for the syntheses of alfentanil sufentanil and remifentanil
Synthetic pathways are disclosed for synthesizing derivatives or analogs of fentanyl. Specifically set out are pathways for synthesizing alfentanil, sufentanil and remifentanil. The disclosed methods require fewer steps and produce a greater yield of prod
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(2008/06/13)

Combination of selected opioids with muscarine antagonists for treating urinary incontinence
Active compound combinations of compounds of group A, particularly opioids, and compounds of group B, particularly anti-muscarine agents and other substances suitable for treatment of an increased urge to urinate or urinary incontinence. Related pharmaceutical formulations and methods of treatment of an increased urge to urinate or urinary incontinence are also provided.
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(2008/06/13)

Chemical Properties

Melting Point: 103-104℃
Boiling Point: 493.1°Cat760mmHg
Flash Point:252°C
Density: 1.132g/cm³
Solubility:Practically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol.
Storage Temp.:2-8°C
Vapor Pressure: 7.23E-10mmHg at 25°C
PKA: 7.89±0.20(Predicted)
PSA: 61.02000
LogP: 4.15270

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