Preparation method of alfentanil and sufentan and compounds used for preparation of sufentanil and alfentan
The invention discloses a preparation method of alfentanil and sufentan and compounds used for preparation of sufentanil and alfentan. Specifically, the method for preparation of a compound shown as formula V includes: carrying out BOC reaction on a compound shown as formula IV to obtain the compound shown as formula V in the specification. The method can conveniently, efficiently and safely prepare an intermediate product for synthesis of alfentanil and sufentan, i.e. the compound shown as formula V. And then, the compound shown as formula V can be effectively used for preparation of alfentanil and sufentan.
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(2017/06/02)
PREPARATION OF SUFENTANIL CITRATE AND SUFENTANIL BASE
Provided herein are processes for forming sufentanil citrate from sufentanil base. One process comprises forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes comprise forming sufentanil citrate in the presence of water.
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Paragraph 0108
(2016/12/16)
SUBSTITUTED 4-AMINO-PIPERIDINES
The present invention relates to new substituted 4-amino-piperidine opioid receptor modulators, pharmaceutical compositions thereof, and methods of use thereof
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Page/Page column 27
(2010/02/17)
IMPROVED METHOD OF MAKING SUFENTANIL
The present invention relates to a process for the preparation of piperidine derivatives including sufentanil and its pharmaceutically acceptable salts, such as it citrate salt
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Page/Page column 11-12
(2010/11/29)
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