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CAS

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56341-08-3

Mabuterol, also known as clenbuterol, is a synthetic medication that belongs to the class of drugs called β2-adrenergic agonists. It is a yellow solid with chemical properties that allow it to interact with specific receptors in the body, leading to relaxation and dilation of the airways. This makes it a promising pharmaceutical candidate for various respiratory applications.

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  • Benzenemethanol,4-amino-3-chloro-alpha-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-

    Cas No: 56341-08-3

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  • 56341-08-3 Structure

  • Basic information

    1. Product Name: MABUTEROL
    2. Synonyms: MABUTEROL;Ambuterol;Benzenemethanol, 4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)- (9CI);PB 868Cl;4-Amino-3-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol;1-[4-azanyl-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol;4-Amino-3-chloro-alpha-[[(tert-butyl)amino]methyl]-5-(trifluoromethyl)benzenemethanol hydrochloride;4-AMino-α-[(tert-butylaMino)Methyl]-5-(trifluoroMethyl)benzene-Methanol
    3. CAS NO:56341-08-3
    4. Molecular Formula: C13H18ClF3N2O
    5. Molecular Weight: 310.74
    6. EINECS: 1312995-182-4
    7. Product Categories: Amines;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 56341-08-3.mol

  • Chemical Properties

    1. Melting Point: 85-87?C
    2. Boiling Point: 375.9 °C at 760 mmHg
    3. Flash Point: 181.1 °C
    4. Appearance: /
    5. Density: 1.278 g/cm3
    6. Vapor Pressure: 2.57E-06mmHg at 25°C
    7. Refractive Index: 1.516
    8. Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
    9. Solubility: N/A
    10. PKA: 13.37±0.20(Predicted)
    11. CAS DataBase Reference: MABUTEROL(CAS DataBase Reference)
    12. NIST Chemistry Reference: MABUTEROL(56341-08-3)
    13. EPA Substance Registry System: MABUTEROL(56341-08-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 56341-08-3(Hazardous Substances Data)

56341-08-3 Usage

Uses

Used in Pharmaceutical Industry:
Mabuterol is used as a bronchodilator and antiasthmatic agent for the treatment of asthma and other respiratory conditions. It works by stimulating the β2-adrenergic receptors in the lungs, leading to the relaxation of smooth muscle and dilation of the airways. This helps to alleviate symptoms such as wheezing, shortness of breath, and coughing associated with asthma and other respiratory disorders.
As a β2-adrenergic agonist, Mabuterol is used as a bronchodilator/antiasthmatic for the following application reasons:
1. To provide relief from bronchoconstriction, which is the narrowing of the airways that occurs during asthma attacks and other respiratory conditions.
2. To improve lung function and overall breathing capacity in patients with asthma and chronic obstructive pulmonary disease (COPD).
3. To reduce inflammation and mucus production in the airways, which can contribute to respiratory symptoms and complications.

Check Digit Verification of cas no

The CAS Registry Mumber 56341-08-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,3,4 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 56341-08:
(7*5)+(6*6)+(5*3)+(4*4)+(3*1)+(2*0)+(1*8)=113
113 % 10 = 3
So 56341-08-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3

56341-08-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name MABUTEROL

1.2 Other means of identification

Product number -
Other names PB 868Cl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56341-08-3 SDS

56341-08-3Relevant articles and documents

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Kruger,Keck,Noll,Pieper

, p. 1612 - 1624 (2007/10/02)

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.

BRONCHOSPASMOLYTIC 1-(P-AMINO-PHENYL)-2-AMINO-ETHANOLS-(1) AND SALTS

-

, (2008/06/13)

Racemic and optically active compounds of the formula wherein R1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano, R2 is fluorine, trifluoromethyl, nitro or cyano, and R3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as beta 2-receptor mimetics and beta 1-receptor blockers

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