97760-87-7

Usage

Chemical Properties

Yellow Solid

Upstream product

• 63498-15-7 4-amino-3-chloro-5-trifluoromethyl-benzoyl chloride 
• 95656-52-3 4-amino-3-chloro-5-(trifluoromethyl)benzoic acid 
• 97760-76-4 4'-amino-3'-chloro-5'-trifluoromethyl-acetophenone 

Downstream Products

• 700795-66-0 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-(2-benzo[1,3]dioxol-5-yl-1-methyl-ethylamino)-ethanone 
• 774480-25-0 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-(1,1-dimethyl-propylamino)-ethanone 
• 792848-89-6 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-cyclobutylamino-ethanone 
• 54240-07-2 4'-amino-3'-chloro-2-cyclopropylamino-5'-trifluoromethyl-acetophenone 
• 848130-79-0 2-chloro-4-oxiran-2-yl-6-(trifluoromethyl)aniline 
• 1246819-58-8 D₉-mabuterol 
• 56707-24-5 l-1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol 
• 56707-24-5 d-1-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol 
• 95656-68-1 Mapenterol 
• 97760-56-0 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-(cyclopropylmethyl-amino)-ethanol 
• 95656-67-0 1-(4'-amino-3'-chloro-5'-trifluoromethyl-phenyl)-2-cyclobutylamino-ethanol 
• 54240-03-8 1-(4'-Amino-3'-chloro-5'-trifluoromethyl-phenyl)-2-isopropylamino-ethanol 
• 54239-32-6 1-(4'-Amino-3'-trifluoromethyl-phenyl)-2-isopropylamino-ethanol 
• 97760-59-3 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-(1,1-diethyl-prop-2-ynylamino)-ethanol 

Relevant academic research and scientific papers

Synthesis of stable isotope labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol

Three stable and simple synthetic routes of labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to 1H NMR and liquid chromatography-tandem mass spectrometry.

Synthesis of deuterium-labelled trantinterol

Trantinterol, a selective β2-adrenoceptor agonist, is currently in Phase II clinical trials for the treatment of asthma and bronchitis. The synthesis of deuterium-labelled trantinterol is described. The labelled trantinterol is used as an inter

NOVEL PHENYLETHANOLAMINE COMPOUNDS HAVING BETA2-ACCEPTOR EXCITATORY FUNCTION AND THEIR PREPARATION METHOD

The invention provides compounds of formula ( I ) and pharmaceutically acceptable salts thereof, wherein R1 is H, chlorine, or bromine; R2 is electron attractive groups selected from the group consisting of CF3, CN, fluori

Heteroarylethanol-pyridylalkylamines for controlling animal growth

A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula STR1 in which A represents =CH-- or =N--, R0 represents hydrogen or methyl, R1 and R3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO2 -alkyl, R2 represents hydrogen, hydroxyl, alkoxy or the radical --NR5 R6, R4 represents hydrogen, C1 -C10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NH7 R8, or represents the radical COR9 or the radical --O--Z--R10, Z represents C1 -C10 -alkylene, -alkenylene or alkynylene, R5 represents hydrogen or alkyl, R6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R5 and R6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring, R7 and R8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl, R9 represents hydroxyl, alkoxy or the radical --NR7 R8, R10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy, with the substituent R4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another, or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.