- Investigation into the structure-activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists
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This paper describes the synthesis and biological evaluation of a series of straight chain analogs of a compound (1) that was previously synthesized in our research program. These compounds, which are T-type calcium channel antagonists, exhibits potent anti-proliferative activity against a variety of cancer cells. A structure-activity relationship of these analogs against a variety of cancer cells has provided insight into a logical pharmacophore for this series of compounds. Furthermore, this series of compounds has presented itself as a set of novel, concentration dependent, dual action agonists/antagonists for the T-type calcium channel.
- McCalmont, William F.,Patterson, Jaclyn R.,Lindenmuth, Michael A.,Heady, Tiffany N.,Haverstick, Doris M.,Gray, Lloyd S.,Macdonald, Timothy L.
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p. 3821 - 3839
(2007/10/03)
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