- Recyclable Hypervalent-Iodine-Mediated Dehydrogenative α,β′-Bifunctionalization of β-Keto Esters under Metal-Free Conditions
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We have developed a method for recyclable hypervalent-iodine-mediated direct dehydrogenative α,β′- bifunctionalization of β-ketoesters and β-diketones under metal-free conditions, which affords a straightforward way to synthesize benzo-fused 2,3-dihydrofurans. This efficient, mild method, which has a wide substrate scope and good functional-group tolerance, was used for the multistep synthesis of the protected aglycone of a naturally occurring phenolic glycoside. A mechanism involving Michael addition to an enone intermediate and subsequent oxidative cyclization is proposed.
- Duan, Ya-Nan,Cui, Li-Qian,Zuo, Lin-Hong,Zhang, Chi
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supporting information
p. 13052 - 13057
(2015/09/07)
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- Thiophenium-ylides: Synthesis and reactivity
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The reaction of propanedioic acid, 2-diazo-1,3-bis(1,1-dimethylethyl) ester (di-tert-butyl diazomalonate) with a series of cyclopenta[b]thiophenes in the presence of catalytic rhodium acetate was studied. The resulting SC ylides underwent a rearrangement to form a heterocycle with different topology; thialene, in very low yields. Experimental and spectral data for all compounds are provided.
- MacHara, Ales,Svoboda, Jiri
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p. 59 - 65,7
(2020/08/24)
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- HIV protease inhibitors
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Compounds of the formula (I): Wherein R1, R2, X and N are as defined in the specification; E is N, CH; A1 and A" are terminal groups as defined in the specification. The compounds have utility as HIV-I protease inhibitors.
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Page/Page column 74-75
(2008/06/13)
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- RECEPTOR FUNCTION CONTROLLING AGENT
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The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.
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Page/Page column 81
(2008/06/13)
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- Rh(I)-catalyzed cyclization of 1-arylprop-2-yn-1-ol derivatives utilizing rhodium 1,4-migration
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A highly useful method for the construction of cyclopentanone derivatives fused with aromatic ring based on hydrorhodation-1,4-rhodium migration sequence is achieved. Treatment of 1-aryl-prop-2-yn-1-ols, which are easily accessible via an addition of acetylides to the corresponding aryl aldehydes, with a catalytic amount of [Rh(cod)2]2(BF4) and P(p-tolyl)3 in the presence of a base gives cyclopentanone derivatives in moderate to good yield. Copyright
- Yamabe, Hokuto,Mizuno, Akio,Kusama, Hiroyuki,Iwasawa, Nobuharu
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p. 3248 - 3249
(2007/10/03)
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- Reaction of the N,N-dimethylacrylamide-trifluoromethanesulfonic anhydride complex with heterocycles of the pyrrole, thiophene, furan, and indole series
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Reactions of the N,N-dimethylacrylarnide-trifluoromethanesulfonic anhydride complex with five-membered aromatic heterocycles of the pyrrole, thiophene, furan, and indole series result in formation of cyclopenta[b]hetarenes or 1,3-diheterylpropanones. The reaction direction depends on the nature of the aromatic substrate. 1998 MAHK Hayka/Interperiodica Publishing.
- Nenaidenko,Baraznenok,Balenkova
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p. 1019 - 1025
(2007/10/03)
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- Efficient one-pot synthesis of cyclopenta[b]thiophen-1-ones and 1,3-di(2-thiophenyl)propan-1-ones from thiophenes
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The reaction of N,N-dimethylacrylamide/triflic anhydride complex with substituted thiophenes led to the corresponding cyclopenta[b]thiophen-1-ones and 1,3-di(2-thiophenyl)propan-1-ones. The application of 2-bromo-N,N-dimethylacrylamide in this reaction allows 2-bromo-substituted five- or seven-membered thiophene-fused cyclic ketones to be obtained.
- Baraznenok, Ivan L.,Nenajdenko, Valentine G.,Balenkova, Elizabeth S.
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p. 465 - 468
(2007/10/03)
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- Reaction of N,N-dimethylacrylamide/trifluoromethanesulfonic anhydride complex with electron-rich aromatic compounds
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The reaction of N,N-dimethylacrylamide/trifluoromethanesulfonic anhydride complex with electron-rich aromatic compounds affords after hydrolysis the corresponding indanones and 1,3-diarylpropanones.
- Nenajdenko, Valentine G.,Baraznenok, Ivan L.,Balenkova, Elizabeth S.
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p. 4199 - 4202
(2007/10/03)
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