5650-51-1

Usage

Uses

Used in Pharmaceutical Research:
AKOS BB-9698 is used as a research compound for its potential pharmacological properties, contributing to drug development and medicinal chemistry studies. Its unique molecular structure and functional groups make it a promising candidate for the discovery of new therapeutic agents.
Used in Drug Development:
In the field of drug development, AKOS BB-9698 is utilized as a potential therapeutic agent. Its properties are being explored for use in the treatment of various diseases and conditions, with ongoing research to determine its full potential and applications in medicine.
Used in Medicinal Chemistry Studies:
AKOS BB-9698 serves as a valuable subject in medicinal chemistry studies, where its chemical properties and biological activities are investigated. This research is crucial for understanding how the compound can be effectively utilized in the creation of new pharmaceuticals and treatments.

InChI:InChI=1/C7H6OS/c8-6-1-2-7-5(6)3-4-9-7/h3-4H,1-2H2

Upstream product

• 188290-36-0 thiophene 
• 2680-03-7 N,N-Dimethylacrylamide 
• 15690-25-2 3-(2-thienyl)acrylic acid 
• 16862-05-8 methyl 3-(2-thienyl)propanoate 
• 5928-51-8 3-(2-thienyl)propanoic acid 
• 498-62-4 3-thiophene carboxaldehyde 
• 849769-14-8 1-(thiophen-3-yl)-3-(trimethylsilyl)prop-2-yn-1-ol 

Downstream Products

• 343929-41-9 5,6-dihydrocyclopenta[b]thiophen-4-one oxime 
• 954238-22-3 5,6-dihydro-4H-cyclopenta[b]thiophen-4-ol 
• 240403-63-8 N-<(4-oxo-4H-5,6-dihydrocyclopentathiophene-5-yl)acetyl>-4-(p-fluorobenzoyl)piperidine 
• 1026795-36-7 C₂₇H₃₅FN₂O₄S 
• 1469857-69-9 3-(4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-6-yl)phenylamine hydrochloride 
• 1469857-13-3 4-(4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-6-yl)phenylamine hydrochloride 
• 1469858-00-1 6-[4-(4-methylpiperazin-1-yl)phenyl]-2-pyridin-3-yl-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene hydrochloride 
• 1469857-99-5 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride 
• 1469857-98-4 5-[6-(4-morpholin-4-ylphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine hydrochloride 
• 1469858-09-0 5-(4-bromobenzoyl)-5,6-dihydrocyclopenta[b]thiophen-4-one 
• 1469857-46-2 (4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-6-yl)(4-trifluoromethylphenyl)amine 
• 1469857-52-0 6-(2-fluorophenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene 
• 1469858-30-7 5-(2-fluorobenzoyl)-5,6-dihydrocyclopenta[b]thiophen-4-one 
• 1469857-16-6 6-(4-nitrophenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene 

Relevant academic research and scientific papers

Recyclable Hypervalent-Iodine-Mediated Dehydrogenative α,β′-Bifunctionalization of β-Keto Esters under Metal-Free Conditions

We have developed a method for recyclable hypervalent-iodine-mediated direct dehydrogenative α,β′- bifunctionalization of β-ketoesters and β-diketones under metal-free conditions, which affords a straightforward way to synthesize benzo-fused 2,3-dihydrofurans. This efficient, mild method, which has a wide substrate scope and good functional-group tolerance, was used for the multistep synthesis of the protected aglycone of a naturally occurring phenolic glycoside. A mechanism involving Michael addition to an enone intermediate and subsequent oxidative cyclization is proposed.

Thiophenium-ylides: Synthesis and reactivity

The reaction of propanedioic acid, 2-diazo-1,3-bis(1,1-dimethylethyl) ester (di-tert-butyl diazomalonate) with a series of cyclopenta[b]thiophenes in the presence of catalytic rhodium acetate was studied. The resulting SC ylides underwent a rearrangement to form a heterocycle with different topology; thialene, in very low yields. Experimental and spectral data for all compounds are provided.

HIV protease inhibitors

Compounds of the formula (I): Wherein R1, R2, X and N are as defined in the specification; E is N, CH; A1 and A" are terminal groups as defined in the specification. The compounds have utility as HIV-I protease inhibitors.

RECEPTOR FUNCTION CONTROLLING AGENT

The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.

Rh(I)-catalyzed cyclization of 1-arylprop-2-yn-1-ol derivatives utilizing rhodium 1,4-migration

A highly useful method for the construction of cyclopentanone derivatives fused with aromatic ring based on hydrorhodation-1,4-rhodium migration sequence is achieved. Treatment of 1-aryl-prop-2-yn-1-ols, which are easily accessible via an addition of acetylides to the corresponding aryl aldehydes, with a catalytic amount of [Rh(cod)2]2(BF4) and P(p-tolyl)3 in the presence of a base gives cyclopentanone derivatives in moderate to good yield. Copyright

Reaction of the N,N-dimethylacrylamide-trifluoromethanesulfonic anhydride complex with heterocycles of the pyrrole, thiophene, furan, and indole series

Reactions of the N,N-dimethylacrylarnide-trifluoromethanesulfonic anhydride complex with five-membered aromatic heterocycles of the pyrrole, thiophene, furan, and indole series result in formation of cyclopenta[b]hetarenes or 1,3-diheterylpropanones. The reaction direction depends on the nature of the aromatic substrate. 1998 MAHK Hayka/Interperiodica Publishing.

Efficient one-pot synthesis of cyclopenta[b]thiophen-1-ones and 1,3-di(2-thiophenyl)propan-1-ones from thiophenes

The reaction of N,N-dimethylacrylamide/triflic anhydride complex with substituted thiophenes led to the corresponding cyclopenta[b]thiophen-1-ones and 1,3-di(2-thiophenyl)propan-1-ones. The application of 2-bromo-N,N-dimethylacrylamide in this reaction allows 2-bromo-substituted five- or seven-membered thiophene-fused cyclic ketones to be obtained.

Reaction of N,N-dimethylacrylamide/trifluoromethanesulfonic anhydride complex with electron-rich aromatic compounds

The reaction of N,N-dimethylacrylamide/trifluoromethanesulfonic anhydride complex with electron-rich aromatic compounds affords after hydrolysis the corresponding indanones and 1,3-diarylpropanones.