- Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas
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Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(II) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, providing a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.
- Chen, Yuncan,Lv, Shan,Lai, Ruizhi,Xu, Yingying,Huang, Xin,Li, Jianglian,Lv, Guanghui,Wu, Yong
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p. 2555 - 2558
(2021/03/17)
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- 4 - substituted -2 - amino thiazole compound preparation method
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The invention discloses a preparation method of a 4-substituted-2-aminothiazole compound. The method comprises the following step: olefin azide shown by the formula I reacts with potassium thiocyanate under the catalysis of palladium acetate to obtain the 4-substituted-2-aminothiazole compound, wherein the molar ratio of the olefin azide compound to potassium thiocyanate to palladium acetate is 20:(59-61):1, the reaction temperature is 75-85 DEG C, and the reaction time is 11-13 hours; and in the formula I, R1 is phenyl, 2-bromophenyl, 3-bromophenyl, 4-bromophenyl, 4-methylphenyl, 4-ethyoxy-3-bromophenyl, 3-nitrophenyl, 4-methoxyacylphenyl, 1-naphthyl, phenylaminomethyl or trans-4-(3-phenylallyloxymethyl).
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Paragraph 0024; 0025; 0026; 0027; 0028; 0029-0044; 0080-0084
(2017/08/24)
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- Citric Acid-catalyzed Synthesis of 2,4-Disubstituted Thiazoles from Ketones via C–Br, C–S, and C–N Bond Formations in One Pot: A Green Approach
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An improved and greener protocol has been developed for the synthesis of 2,4-disubstituted thiazoles via C–Br, C–S, and, C–N bond formations in a single step from readily available ketones, N-bromosuccinimide (NBS), and thiourea catalyzed by citric acid in a mixture of ethanol and water (3:1) under reflux conditions. This method has the advantages of freedom from the isolation of lachrymatory α-bromoketones, ease of carrying out, cleaner reaction profile, broad substrate scope, freedom from chromatographic purification, and suitability for large-scale synthesis.
- Gundala, Trivikram Reddy,Godugu, Kumar,Nallagondu, Chinna Gangi Reddy
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p. 1408 - 1416
(2017/10/23)
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- Green and expeditious synthesis of some 2-amino/ arylamino-4-(1-naphthyl)thiazole derivatives using [hydroxy(tosyloxy)iodo]benzene
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The synthesis of a series of 2-amino/arylamino-4-(1-naphthyl)thiazole 4 under solvent-free and eco-friendly conditions by applying 'Grindstone Chemistry Technique' using [hydroxy(tosyloxy)iodo]benzene is described practicing the modified Hantzsch thiazole
- Pundeer, Rashmi,Vijaykiran
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p. 311 - 315
(2019/01/18)
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- Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts
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A highly selective construction of 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles, respectively, catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiocyanate has been developed. Use of readily available starting materials, high selectivity, as well as mild reaction conditions make this practical method particularly attractive.
- Chen, Binhui,Guo, Shanshan,Guo, Xiao,Zhang, Guolin,Yu, Yongping
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supporting information
p. 4698 - 4701
(2015/10/12)
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- A novel and efficient one pot synthesis of 2,4-disubstituted thiazoles and oxazoles using phenyltrimethylammoniumtribromide in ionic liquid
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A novel and efficient one-pot procedure has been described for synthesis of 2,4-disubstituted thiazoles and oxazoles from substituted ketones using phenyltrimethylammoniumtribromide as in situ brominating agent followed by reaction with thioamide/thiourea and amides/ureas, respectively in [bmim][BF4] ionicliquid. The advantages of the procedure include avoiding the handling of lacrymetric compounds, hazardous and toxic organic solvents along with good to excellent yield of the products.
- Muthyala, Manoj Kumar,Kumar, Anil
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p. 959 - 964
(2012/10/29)
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- MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
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Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an en
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Page/Page column 52
(2009/04/24)
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- Inhibitory effect of 2-aminothiazole derivatives in oxidation reactions
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The kinetics and mechanism of inhibitory effect of 2-aminothiazole derivatives in the radical-initiated oxidation of cumene were studied.
- Karpov,Pekarevskii,Potekhin
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p. 1484 - 1486
(2007/10/03)
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- Biocidal and anticorrosive effect of 2-aminothiazole derivatives used as additives to jet fuels
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The effect of 2-aminothiazole derivatives on the biological resistance and corrosion activity of jet fuels was studied under conditions of water condensation.
- Karpov,Nazarenko,Pekarevskii,Potekhin
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p. 998 - 1001
(2007/10/03)
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