Synthesis of the β2-Agonist Tulobuterol and Its Metabolite 4-Hydroxytulobuterol
Abstract: Alternative methods have been developed for the synthesis of theβ2-agonist tulobuterol and its metabolite4-hydroxytulobuterol with a similar activity. The proposed procedures utilizeavailable reagents, and the key stage in the synthesis is the formation ofintermediate oxirane according to the Corey–Chaykovsky reaction, followed byopening of the oxirane ring by the action of excess tert-butylamine. In the synthesis of 4-hydroxytulobuterol, thehydroxy group was protected by benzylation, and the protecting group was removedin the final stage by hydrogenation over carbon-supported palladium.
Burdeinyi, M. L.,Glushkova, M. A.,Popkov, S. V.
p. 390 - 394
(2020/04/27)
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