56862-28-3

Basic information

• Product Name: (-)-N-DeMethyl Deprenyl
• Synonyms: (-)-N-DeMethyl Deprenyl;R-(-)-N-DeMethyl Deprenyl;N-DesMethyl Selegiline HCl;Selegiline Related CoMpound D
• CAS NO: 56862-28-3
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.2542
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 56862-28-3.mol

Chemical Properties

• Boiling Point: 275.3°Cat760mmHg
• Flash Point: 121.7°C
• Appearance: /
• Density: 0.955g/cm³
• Vapor Pressure: 0.00513mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (-)-N-DeMethyl Deprenyl(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-N-DeMethyl Deprenyl(56862-28-3)
• EPA Substance Registry System: (-)-N-DeMethyl Deprenyl(56862-28-3)

Safety Data

• Hazardous Substances Data: 56862-28-3(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

InChI:InChI=1/C12H15N/c1-3-9-13-11(2)10-12-7-5-4-6-8-12/h1,4-8,11,13H,9-10H2,2H3/t11-/m1/s1

Upstream product

• 115586-38-4 (-)-Desmethylselegiline hydrochloride 
• 68-11-1 mercaptoacetic acid 
• 3182-95-4 L-Phenylalaninol 
• 63-91-2 L-phenylalanine 
• 73058-30-7 (2S)-2-benzylazacyclopropane 

Downstream Products

• 2323-36-6 SELEGILINE 
• 1146971-74-5 N-[ 2-[18F]fluoroethyl]-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine 
• 1146971-73-4 N-(2-fluoroethyl)-N-(1-phenylpropan-2-yl)prop-2-yn-1-amine 
• 851086-87-8 S-rivastigmine-desmethylselegiline 

Relevant articles and documents

Selegiline hydrochloride synthesis process

The invention relates to the field of chemical pharmacy, particularly to a selegiline hydrochloride preparation method. According to the invention, the method avoids the use of ephedrine, pseudoephedrine, deoxyephedrine and other management and control products, has characteristics of inexpensive and easily-available raw materials, short synthesis route, safe and environmentally-friendly production and synthesis cost reducing, can obtain the high-purity target compound at high yield, and is suitable for industrial large-scale production.

Ring opening of pymisyl-protected aziridines with organocuprates

The pyrimidine-2-sulfonyl (pymisyl) group is introduced as a new protecting group that can be used to activate aziridines towards ring opening. It is readily introduced and removed under mild conditions. Regioselective ring opening of pymisyl-protected 2-methyl-aziridine with organocuprates gives the corresponding sulfonamides in high yields, and the pymisyl group can subsequently be removed upon treatment with a thiolate. The versatility of this new nitrogen protecting group is illustrated with a new synthesis of Selegiline, a monoamine oxidase-B inhibitor marketed for the treatment of Parkinson's disease. Easy on'easy off: The pymisyl group is introduced as a new protecting group for the activation of aziridines towards ring opening with organocuprates (see scheme). It is readily removed under very mild conditions with thiolates. The versatility of the approach is illustrated in a new synthesis of Selegiline, a drug marketed for the treatment of Parkinson's disease.

COMPOUNDS FOR USE IN IMAGING, DIAGNOSING, AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM OR OF TUMORS

This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds