- Improved charge transport in fused-ring bridged hemi-isoindigo-based small molecules by incorporating a thiophene unit for solution-processed organic field-effect transistors
-
Two acceptor-donor-acceptor small molecules based on a fused ring indacenodithieno[3,2-b]thiophene (IDTT) as a donor, and hemi-isoindigo units, methyleneoxindole (IDTT-MI) and thienylmethyleneoxindole (IDTT-T-MI) as acceptors were synthesized and characte
- Zhang, Guobing,Chen, Ruikun,Sun, Yue,Kang, Boseok,Sun, Mingxiang,Lu, Hongbo,Qiu, Longzhen,Cho, Kilwon,Ding, Yunsheng
-
-
Read Online
- Synthesis of N-substituted 3-(2-aryl-2-oxoethyl)- 3-hydroxyindolin-2-ones and their conversion to N-substituted (E)-3-(2-aryl-2-oxoethylidene)-indolin-2-ones: Synthetic sequence, spectroscopic characterization and structures of four 3-hydroxy compounds an
-
An operationally simple and time-efficient approach has been developed for the synthesis of racemic N-substituted 3-(2-aryl-2-oxoethyl)-3-hydroxyindolin-2- ones by a piperidine-catalysed aldol reaction between aryl methyl ketones and N-alkylisatins. These
- Becerra, Diana,Castillo, Juan,Cobo, Justo,Glidewell, Christopher,Insuasty, Braulio
-
p. 433 - 445
(2020/05/18)
-
- Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides
-
Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N-protected and protection-free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst.
- Schilling, Waldemar,Zhang, Yu,Riemer, Daniel,Das, Shoubhik
-
supporting information
p. 390 - 395
(2019/12/15)
-
- A-D-A type conjugated small-molecule semiconductor material based on fused rings and indol-2-one
-
The invention discloses an A-D-A type conjugated small-molecule semiconductor material based on fused rings and indol-2-one. The conjugated small-molecule material has advantages of traditional smallmolecules and conjugated polymers, has a clear molecular
- -
-
Paragraph 0026-0028
(2020/02/14)
-
- TBHP Mediated Substrate Controlled Oxidative Dearomatization of Indoles to C2/C3-Quaternary Indolinones
-
Oxidative dearomatization of indoles with 70 % aqueous tert-butylhydroperoxide (TBHP) in the absence of any metal salts/organic solvents gave the corresponding C2/C3-quaternary indolinones under open-air reaction conditions. The nature of substituent on the indole nitrogen dictates the type of product formed in these reactions. Free (NH)-indoles gave C2-quaternary indolinone derivatives whilst (NR)-indoles yielded C3-quaternary indolinones as the major product. Moreover, the addition of an excess amount of TBHP also facilitated the one-pot transformation of (NR)-indoles to the corresponding isatin derivatives.
- Kothandapani, Jagatheeswaran,Reddy, Singarajanahalli Mundarinti Krishna,Thamotharan, Subbiah,Kumar, Shankar Madan,Byrappa, Kullaiah,Ganesan, Subramaniapillai Selva
-
supporting information
p. 2762 - 2767
(2018/06/21)
-
- Novel indolin-2-one-substituted methanofullerenes bearing long N-alkyl chains: Synthesis and application in bulk-heterojunction solar cells
-
An easy, high-yield and atom-economic procedure of a C60 fullerene modification using a reaction of fullerene C60 with N-alkylisatins in the presence of tris(diethylamino)phosphine to form novel long-chain alkylindolinone-substituted methanofullerenes (AIMs) is described. Optical absorption, electrochemical properties and solubility of AIMs were studied. Poly(3-hexylthiophene-2,5-diyl) (P3HT)/AIMs solar cells were fabricated and the effect of the AIM alkyl chain length and the P3HT:AIM ratio on the solar cell performance was studied. The power conversion efficiencies of about 2% were measured in the P3HT/AIM devices with 1:0.4 P3HT:AIM weight ratio for the AIMs with hexadecyl and dodecyl substituents. From the optical and AFM data, we suggested that the AIMs, in contrast to [6,6]-phenyl-C61-butyric acid methyl ester (PCBM), do not disturb the P3HT crystalline domains. Moreover, the more soluble AIMs do not show a better miscibility with the P3HT crystalline phase.
- Romanova, Irina P.,Bogdanov, Andrei V.,Izdelieva, Inessa A.,Trukhanov, Vasily A.,Shaikhutdinova, Gulnara R.,Yakhvarov, Dmitry G.,Latypov, Shamil K.,Mironov, Vladimir F.,Dyakov, Vladimir A.,Golovnin, Ilya V.,Paraschuk, Dmitry Yu,Sinyashin, Oleg G.
-
p. 1121 - 1128
(2014/06/09)
-
- Scaffold-inspired enantioselective synthesis of biologically important spiro[pyrrolidin-3,2'-oxindoles] with structural diversity through catalytic isatin-derived 1,3-dipolar cycloadditions
-
Catalytic asymmetric construction of the biologically important spiro[pyrrolidin-3,2'-oxindole] scaffold with contiguous quaternary stereogenic centers in excellent stereoselectivities (up to >99:1 d.r., 98 % ee) has been established by using an organocat
- Shi, Feng,Tao, Zhong-Lin,Luo, Shi-Wei,Tu, Shu-Jiang,Gong, Liu-Zhu
-
supporting information; experimental part
p. 6885 - 6894
(2012/07/27)
-
- Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain
-
Starting from the oxindole 2a identified through a high-throughput screening campaign, a series of NaV1.7 blockers were developed. Following the elimination of undesirable structural features, preliminary optimization of the oxindole C-3 and N-1 substituents afforded the simplified analogue 9b, which demonstrated a 10-fold increase in target potency versus the original HTS hit. A scaffold rigidification strategy then led to the discovery of XEN907, a novel spirooxindole NaV1.7 blocker. This lead compound, which in turn showed a further 10-fold increase in potency, represents a promising structure for further optimization efforts.
- Chowdhury, Sultan,Chafeev, Mikhail,Liu, Shifeng,Sun, Jianyu,Raina, Vandna,Chui, Ray,Young, Wendy,Kwan, Rainbow,Fu, Jianmin,Cadieux, Jay A.
-
scheme or table
p. 3676 - 3681
(2011/08/06)
-
- USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS
-
This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
- -
-
-
- HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS
-
Hydrazone compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.
- -
-
Page/Page column 45, 46
(2009/03/07)
-
- Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain
-
There is growing interest in using cannabinoid receptor 2 (CB2) agonists for the treatment of neuropathic pain. We have synthesized a novel series of N-alkyl isatin acylhydrazone derivatives and have identified and characterized several of them as novel analogues with high functional activity and selectivity at human CB2 receptors using [35S]GTP-γ-S assays. Binding affinities at human CB2 and CB1 were determined for compounds 28, 33, 40, 48, and 58. Structure-activity relationship studies of this novel series led to optimization of our lead compound, compound 33 (MDA19). Compound 33 possessed potent antiallodynic effects in a rat model of neuropathic pain but did not affect rat locomotor activity. More potent and more CB2-receptor-selective compounds, including compounds 37, 40, and 48, were also discovered.
- Diaz, Philippe,Xu, Jijun,Astruc-Diaz, Fanny,Pan, Hao-Min,Brown, David L.,Naguib, Mohamed
-
supporting information; experimental part
p. 4932 - 4947
(2009/07/11)
-
- Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors
-
The oxindolylidene acetic acids having long N-alkyl chains exhibited strong inhibitory activity toward dual specificity phosphatase Cdc25A.
- Shimazawa, Rumiko,Kuriyama, Masami,Shirai, Ryuichi
-
body text
p. 3350 - 3353
(2009/04/07)
-
- OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
-
This invention is directed to oxindole compounds that are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also disclosed.
- -
-
Page/Page column 71; 80
(2010/11/24)
-
- Novel Dyestuffs Containing Dicyanomethylidene Groups
-
Several series of novel compounds have been prepared containing dicyanomethylidene groups including 1-alkyl-3-dicyanomethylideneindol-2-ones and 6,6-dicyanofulvenes.Their visible absorption properties are recorded and discussed.
- Katritzky, Alan R.,Fan, Wei-Qiang,Liang, De-Sheng,Li, Qiao-Ling
-
p. 1541 - 1546
(2007/10/02)
-