569370-38-3

Basic information

• Product Name: 3-(HYDROXYMETHYL)-5-(TRIFLUOROMETHYL)BENZONITRILE
• Synonyms: 3-(TRIFLUOROMETHYL)-5-(HYDROXYMETHYL)BENZONITRILE;3-(HYDROXYMETHYL)-5-(TRIFLUOROMETHYL)BENZONITRILE
• CAS NO: 569370-38-3
• Molecular Formula: C₉H₆F₃NO
• Molecular Weight: 201.15
• Mol File: 569370-38-3.mol

Chemical Properties

• Boiling Point: 265.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 13.81±0.10(Predicted)
• CAS DataBase Reference: 3-(HYDROXYMETHYL)-5-(TRIFLUOROMETHYL)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(HYDROXYMETHYL)-5-(TRIFLUOROMETHYL)BENZONITRILE(569370-38-3)
• EPA Substance Registry System: 3-(HYDROXYMETHYL)-5-(TRIFLUOROMETHYL)BENZONITRILE(569370-38-3)

Safety Data

• Hazardous Substances Data: 569370-38-3(Hazardous Substances Data)

Upstream product

• 172023-97-1 (3‐bromo‐5‐(trifluoromethyl)phenyl)methanol 
• 557-21-1 dicyanozinc 
• 73963-98-1 zinc cyanide 

Downstream Products

• 942077-16-9 3-cyano-5-(trifluoromethyl)benzoic acid 
• 1057667-30-7 3-acetyl-5-(trifluoromethyl)benzonitrile 
• 1057667-29-4 3-cyano-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide 
• 949089-40-1 3-azidomethyl-5-trifluoromethyl-benzonitrile 
• 669080-79-9 3-bromomethyl-5-trifluoromethyl-benzonitrile 

Relevant articles and documents

Dibenzyl Amine Compounds and Derivatives

Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

NK-1 AND SEROTONIN TRANSPORTER INHIBITORS

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.

TRISUBSTITUTED AMINE COMPOUND

The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted heterocyclic group, and the like; R1 is an optionally substituted alkyl group, wherein the alkyl group further may optionally be substituted by an optionally substituted homocyclic group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

A PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES

The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof. Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.