172023-97-1Relevant articles and documents
Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations
Swier,Monjas,Ree?ing,Oudshoorn,Aisyah,Primke,Bakker,Van Olst,Ritschel,Faustino,Marrink,Hirsch,Slotboom
, p. 1121 - 1130 (2017)
Energy-coupling factor (ECF) transporters are involved in the uptake of micronutrients in bacteria. The transporters capture the substrate by high-affinity binding proteins, the so-called S-components. Here, we present the analysis of two regions of the s
Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors
Degnan, Andrew P.,Tora, George O.,Han, Ying,Rajamani, Ramkumar,Bertekap, Robert,Krause, Rudolph,Davis, Carl D.,Hu, Joanna,Morgan, Daniel,Taylor, Sarah J.,Krause, Kelly,Li, Yu-Wen,Mattson, Gail,Cunningham, Melissa A.,Taber, Matthew T.,Lodge, Nicholas J.,Bronson, Joanne J.,Gillman, Kevin W.,Macor, John E.
, p. 3039 - 3043 (2015/06/22)
Depression is a serious illness that affects millions of patients. Current treatments are associated with a number of undesirable side effects. Neurokinin 1 receptor (NK1R) antagonists have recently been shown to potentiate the antidepressant e
DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES
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Page/Page column 60, (2012/04/04)
The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.