- Facile synthesis of spiro thiazolidinone via cyclic ketones, amines and thioglycolic acid by MCM-41-Schiff base-CuSO4·5H2O
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Mesoporous MCM-41-supported Schiff base and CuSO4?5H2O (MCM-41@Schiff base-CuSO4?5H2O) catalyzed one-pot three-component condensation of cyclic ketones, amines and thioglycolic acid in toluene. And a series of corresponding spiro thiazolidinone derivatives were obtained in high yields (up to 97%). The synthesized catalyst was characterized via FT-IR, XRD, SEM, TEM and EDS and can be easily recovered by centrifugation and reused at 10 times without any change in catalytic activity. Moreover, the scale-up experiment also demonstrated the practicability of the catalytic system on the condensation. The possible mechanisms pave the way to investigation on the reactions of other cyclic ketones with thioglycolic acid.
- Hui, Yonghai,Zhang, Yongfei,Luo, Yongyue,Li, Jianpeng,Wang, Yun,Gao, Tianming,Xia, Jialiang,Wang, Sheng,Zhang, Shiqi
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p. 521 - 532
(2020/10/19)
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- The first one-pot, solvent-free microwave-accelerated, three- componentsynthesis of spirothiazolidin-4-ones via Staudinger/aza-Wittig coupling/cyclization
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An efficient and rapid, solvent-free, microwave-accelerated, one-pot, three-component protocol for the synthesis of spirothiazolidin-4-ones from organic azides is reported for the first time via Staudinger/aza-Wittig coupling/cyclization. The solvent-free
- Ponnuswamy, Alagusundaram,Shanmugavelan, Poovan,Nagarajan, Sangaraiah,Sathishkumar, Murugan
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experimental part
p. 922 - 928
(2012/08/08)
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- Carbodiimide mediated synthesis of 4-thiazolidinones by one-pot three-component condensation
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In the present study, 4-thiazolidinones have been assembled by DCC mediated three-component reaction of amine, aldehyde and mercaptoacetic acid. The final compounds are obtained in quantitative yields within one hour.
- Srivastava, Tumul,Haq,Katti
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p. 7619 - 7624
(2007/10/03)
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