57178-07-1Relevant academic research and scientific papers
Facile synthesis of spiro thiazolidinone via cyclic ketones, amines and thioglycolic acid by MCM-41-Schiff base-CuSO4·5H2O
Hui, Yonghai,Zhang, Yongfei,Luo, Yongyue,Li, Jianpeng,Wang, Yun,Gao, Tianming,Xia, Jialiang,Wang, Sheng,Zhang, Shiqi
, p. 521 - 532 (2020/10/19)
Mesoporous MCM-41-supported Schiff base and CuSO4?5H2O (MCM-41@Schiff base-CuSO4?5H2O) catalyzed one-pot three-component condensation of cyclic ketones, amines and thioglycolic acid in toluene. And a series of corresponding spiro thiazolidinone derivatives were obtained in high yields (up to 97%). The synthesized catalyst was characterized via FT-IR, XRD, SEM, TEM and EDS and can be easily recovered by centrifugation and reused at 10 times without any change in catalytic activity. Moreover, the scale-up experiment also demonstrated the practicability of the catalytic system on the condensation. The possible mechanisms pave the way to investigation on the reactions of other cyclic ketones with thioglycolic acid.
The first one-pot, solvent-free microwave-accelerated, three- componentsynthesis of spirothiazolidin-4-ones via Staudinger/aza-Wittig coupling/cyclization
Ponnuswamy, Alagusundaram,Shanmugavelan, Poovan,Nagarajan, Sangaraiah,Sathishkumar, Murugan
experimental part, p. 922 - 928 (2012/08/08)
An efficient and rapid, solvent-free, microwave-accelerated, one-pot, three-component protocol for the synthesis of spirothiazolidin-4-ones from organic azides is reported for the first time via Staudinger/aza-Wittig coupling/cyclization. The solvent-free
Carbodiimide mediated synthesis of 4-thiazolidinones by one-pot three-component condensation
Srivastava, Tumul,Haq,Katti
, p. 7619 - 7624 (2007/10/03)
In the present study, 4-thiazolidinones have been assembled by DCC mediated three-component reaction of amine, aldehyde and mercaptoacetic acid. The final compounds are obtained in quantitative yields within one hour.
