A simple route for synthesis of 4-phospho-D-erythronate
4-Phospho-d-erythronate is an intermediate in the synthesis of pyridoxal 5′-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-d-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-d-erythronate from the inexpensive precursor d-erythronolactone in five steps with a preparatively useful yield of 22%.
Novikov, Yehor,Copley, Shelley D.,Eaton, Bruce E.
supporting information; experimental part
p. 1913 - 1915
(2011/04/22)
Reactivity of some sugars and sugar phosphates towards gold(III) in sodium acetate-acetic acid buffer medium
The kinetics of the oxidation of some aldoses and aldose phosphates have been studied spectrophotometrically in sodium acetate-acetic acid buffer medium at different temperatures. The reactions are first order with respect to [Au(III)] and [substrate]. Both H+ and Cl- ions retard the reaction. The reactions appear to involve different gold(III) species, viz. AuCl4/-, AuCl3(OH2) and AuCl3(OH)-. The results are interpreted in terms of the probable intermediate formation of free radicals and Au(II). Aldoses react with gold(III) in the order: triose > tetrose > pentose > hexose. The sugar phosphates react with gold(III) at a faster rate than the parent sugars except glucose-1-phosphate, which reacts at slower rates than glucose. A tentative reaction mechanism leading to the formation of products has been suggested.
Sen Gupta, Kalyan Kali,Pal, Biswajit,Begum, Bilkis Ara
p. 115 - 123
(2007/10/03)
Reactivities of some sugar phosphates towards permanganate in perchloric acid medium and mechanism of the oxidation processes
The reactivities of some sugar phosphates towards permanganate have been examined in perchloric acid medium. The reactions are first order in [sugar phosphate] and [MnO4-]. The rate increases with increase in [H+]. The reactivities follow the order: erythrose 4-phosphate> ribose 5-phosphate> fructose 1,6-diphosphate> glucose 6-phosphate> glucose 1-phosphate. The mechanism of the reactions is discussed.
Sen Gupta, Kalyan Kali,Tribedi, Partha Sarathi,Sen Gupta, Shipra
p. 427 - 430
(2007/10/03)
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