57229-25-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Phospho D-Erythronate is used as an intermediate for the synthesis of pyridoxal 5'-phosphate in some bacteria. This is important for the production of vitamin B6, which plays a crucial role in various metabolic processes in the human body.
Used in Enzyme Inhibition:
4-Phospho D-Erythronate is used as an inhibitor of ribose 5-phosphate isomerase, which is involved in the pentose phosphate pathway. This application is significant for studying the enzyme's function and its role in cellular metabolism.
Used in Trypanosoma brucei Inhibition:
4-Phospho D-Erythronate is used as a strong inhibitor of the Trypanosoma brucei enzyme, which is associated with African sleeping sickness. By inhibiting this enzyme, 4PE can potentially help in the development of treatments for this disease.
Used in Research and Development:
4-Phospho D-Erythronate is used as a research tool to study the mechanisms of various enzymes and their roles in cellular metabolism. This can lead to a better understanding of metabolic pathways and the development of new therapeutic strategies for various diseases.

Upstream product

• 669695-13-0 Methyl-2,3-O-benzoyl-4-O-trityl-D-erythronat 
• 585-18-2 D-erythrose 4-phosphate 
• 1293913-18-4 C₃₉H₃₉O₈P 
• 92986-77-1 Glucosaccharinsaeure-6-phosphat 

Relevant academic research and scientific papers

A simple route for synthesis of 4-phospho-D-erythronate

4-Phospho-d-erythronate is an intermediate in the synthesis of pyridoxal 5′-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-d-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-d-erythronate from the inexpensive precursor d-erythronolactone in five steps with a preparatively useful yield of 22%.

Reactivity of some sugars and sugar phosphates towards gold(III) in sodium acetate-acetic acid buffer medium

The kinetics of the oxidation of some aldoses and aldose phosphates have been studied spectrophotometrically in sodium acetate-acetic acid buffer medium at different temperatures. The reactions are first order with respect to [Au(III)] and [substrate]. Both H+ and Cl- ions retard the reaction. The reactions appear to involve different gold(III) species, viz. AuCl4/-, AuCl3(OH2) and AuCl3(OH)-. The results are interpreted in terms of the probable intermediate formation of free radicals and Au(II). Aldoses react with gold(III) in the order: triose > tetrose > pentose > hexose. The sugar phosphates react with gold(III) at a faster rate than the parent sugars except glucose-1-phosphate, which reacts at slower rates than glucose. A tentative reaction mechanism leading to the formation of products has been suggested.

Reactivities of some sugar phosphates towards permanganate in perchloric acid medium and mechanism of the oxidation processes

The reactivities of some sugar phosphates towards permanganate have been examined in perchloric acid medium. The reactions are first order in [sugar phosphate] and [MnO4-]. The rate increases with increase in [H+]. The reactivities follow the order: erythrose 4-phosphate> ribose 5-phosphate> fructose 1,6-diphosphate> glucose 6-phosphate> glucose 1-phosphate. The mechanism of the reactions is discussed.