- CuI/N,N-dimethylglycine-catalyzed synthesis of N-aryloxazolidinones from aryl bromides
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CuI/N,N-dimethylglycine catalyzed coupling of aryl bromides with substituted oxazolidinones took place at 120 °C in DMF, affording the corresponding N-arylation products with good to excellent yields. A number of functional groups, such as ketone, nitrile, nitro, methoxy, and hydroxyl were tolerated under these conditions, thereby allowing diversity synthesis of N-aryloxazolidinones.
- Li, Jiaojiao,Zhang, Yihua,Jiang, Yongwen,Ma, Dawei
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supporting information; experimental part
p. 3981 - 3983
(2012/08/27)
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- Palladium-catalyzed synthesis of N-aryloxazolidinones from aryl chlorides
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(Matrix presented) An efficient method for intermolecular N-arylation of oxazolidinones using Pd2dba3 and various phosphine ligands in the presence of a weak base is reported. The conditions allow the use of cheaper aryl chlorides containing functionalities such as enolizable ketones, amides, etc., which would be incompatible with other coupling methods. The coupling reaction can be used to prepare enantiopure N-aryl β-amino alcohols. Depending on the stereoelectronic nature of the aryl chloride, careful choice of ligand was necessary for the success of these reactions.
- Ghosh, Arun,Sieser, Janice E.,Riou, Maxime,Cai, Weiling,Rivera-Ruiz, Luis
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p. 2207 - 2210
(2007/10/03)
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