- Synthesis method of 4-chlorothiophene-2-carbonyl derivative
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The invention discloses a synthesis method of a 4-chlorothiophene-2-carbonyl derivative. A thiophene-2-carbonyl derivative is used as a raw material and reacts with symclosene and aluminum trichloride, and liquid separation and concentration are performed to obtain the 4-chlorothiophene-2-carbonyl derivative. The synthesis method adopts one-step reaction, the yield is not lower than 80%, the production process is decreased while the yield is improved, and the cost is reduced; the used raw materials and reagents are easy to obtain, reaction conditions are mild, post-treatment and purification is easy to operate, and large-scale production can be achieved.
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Paragraph 0038-0040
(2019/03/08)
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- Substituted oxoazaheterocyclyl compounds
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This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..
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Page/Page column 76
(2008/06/13)
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