- Variable noninnocence of substituted azobis(phenylcyanamido)diruthenium complexes
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The synthetic chemistry of substituted 4,4′-azobis(phenylcyanamide) ligands was investigated, and the complexes [{Ru(tpy)(bpy)}2( μ-L)][PF6]2, where L = 2,2′:5,5′-tetramethyl-4,4′-azobis(phenylcyanamido) (Me4adpc2-), 2,2′-dimethyl-4,4′-azobis(phenylcyanamido) (Me2adpc2-), unsubstituted (adpc2-), 3,3′-dichloro-4,4′-azobis(phenylcyanamido) (Cl2adpc2-), and 2,2′:5,5′-tetrachloro-4,4′-azobis(phenylcyanamido) (Cl4adpc2-), were prepared and characterized by cyclic voltammetry and vis-near-IR (NIR) and IR spectroelectrochemistry. The room temperature electron paramagnetic resonance spectrum of [{Ru(tpy)(bpy)}2( μ-Me4adpc)]3+ showed an organic radical signal and is consistent with an oxidation-state description [RuII, Me4adpc?-, RuII]3+, while that of [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ at 10 K showed a low-symmetry RuIII signal, which is consistent with the description [RuIII, Cl2adpc2-, RuII]3+. IR spectroelectrochemistry data suggest that [{Ru(tpy)(bpy)}2( μ-adpc)]3+ is delocalized and [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ and [{Ru(tpy)(bpy)}2( μ-Cl4adpc)]3+ are valence-trapped mixed-valence systems. A NIR absorption band that is unique to all [{Ru(tpy)(bpy)}2( μ-L)]3+ complexes is observed; however, its energy and intensity vary depending on the nature of the bridging ligand and, hence, the complexes oxidation-state description.
- Choudhuri, Mohommad M. R.,Behzad, Mahdi,Al-Noaimi, Mousa,Yap, Glenn P. A.,Kaim, Wolfgang,Sarkar, Biprajit,Crutchley, Robert J.
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supporting information
p. 1508 - 1517
(2015/06/16)
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- ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Formula (I), and salts thereof, wherein R1, RA2, RA3 and RA4, are defined herein, which have properties for positive allosteric modulation of mGluR-4 receptor sites. Also described are pharmaceutical formulations comprising the compounds of Formula (I) or their salts, and methods of treating Parkinson's disease and related disorders using the same.
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Paragraph 0113
(2013/05/21)
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- ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Disclosed are compounds of Formula (I), and salts thereof, wherein R1, RA2, RA3 and RA4, are defined herein, which have properties for positive allosteric modulation of mGluR-4 receptor sites. Also described are pharmaceutical formulations comprising the compounds of Formula (I) or their salts, and methods of treating Parkinson's disease and related disorders using the same.
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Paragraph 0113
(2013/05/21)
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- Quinone Imine Route to Benzimidazol-2-ylcarbamates. Part 1. Synthesis of Open-chain and Cyclic 5-Acylamino Derivatives.
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The synthesis of the N',N''-bismethoxycarbonyl-N-(4-acylaminophenyl)guanidines (4) and (7) is described.Oxidation of these with LTA has led to the benzimidazol-2-ylcarbamates. (8), (9) and (10) through a regiospecific cyclisation of quinone imine intermediates.If the acylamino group is part of a ring, the yield of benzimidazoles (15) increases with the size of the lactam ring.The direction of ring closure may be controlled by electronic and steric factors.
- Rajappa, Srinivasachari,Sreenivasan, Ramaswami,Khalwadekar, Asha
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p. 1657 - 1675
(2007/10/02)
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