57629-91-1Relevant articles and documents
Chemistry of Nitrosamines, V.-Syntheses of α-Functional N-Nitrosodialkylamines: Thioethers and Dithiocarbamates
Rugewitz-Blackholm, Beate,Wiessler, Manfred
, p. 583 - 588 (2007/10/02)
The in vivo reaction products of electrophilic compounds with glutathione are excreted as S-alkyl-N-acetylcysteins (mercapturates) after enzymatic degradation.The results clearly show that mercapturates as 1-substituted N-nitrosodialkylamines 11 are chemically stable enough to be isolated and characterized.The reactions of 1-chloro-N-nitrosodialkylamines 5 with 3,4-dichlorothiophenol, ethanethiol, and N,N-diethyldithiocarbamate illustrate the high tendency of formation of 1-thiosubstituted nitrosamines.
The Chemistry of Nitrosamines, IV. - Syntheses of α-C-Functionalized N-Nitrosodialkylamines: Esters and Ethers of 1-alcohols
Mueller, Eduard,Kettler, Regina,Wiessler, Manfred
, p. 1468 - 1493 (2007/10/02)
Imines (Schiff's bases) and nitrosyl chloride react to give N-alkyl-1-chloro-N-nitrosoalkylamines 13.Nucleophilic substitution by acetate or p-nitrobenzoate affords the acetates 7 and 9 and p-nitrobenzoates 8 and 10, respectively.The spectroscopic and chemical data of the newly synthesized compounds are discussed.