The evaluation of 5-amino- and 5-hydroxyuracil derivatives as potential quadruplex-forming agents
5-Substituted uracils (NH2 or OH groups in position 5) have been examined theoretically and experimentally as potential building blocks in quadruplex structures. Our high level Density Functional Theory (DFT) calculations showed that the tetram
Paragi, Gábor,Kupihár, Zoltán,Endre, Gábor,Fonseca Guerra, Célia,Kovács, Lajos
p. 2174 - 2184
(2017/03/17)
Noncovalent and site-directed spin labeling of nucleic acids
Spin label parking: The rigid spin label c (magenta), which is an analogue of cytidine, binds site-specifically to abasic sites in duplex DNAs, through hydrogen bonding to guanine (blue) and π stacking with the flanking base pairs. EPR spectroscopy shows
Shelke, Sandip A.,Sigurdsson, Snorri Th.
supporting information; experimental part
p. 7984 - 7986
(2011/01/10)
Macrocyclic 5-bromouracil derivatives: synthesis and transformation of a uracil ring
Cyclization of 1,3-bis(ω-bromoalkyl)-5-bromouracil with p-methoxybenzylamine or sodium sulfide led to a series of pyrimidinophanes containing heteroatoms in bridges. An unusual behaviour of the 5-bromouracil ring, namely its contraction into hydantoin units during the cyclization reactions with p-methoxybenzylamine was observed. Sodium sulfide does not affect the 5-bromouracil ring, and no transformation products were observed in the synthesis of pyrimidinophanes with sulfur bridges. A possible reaction mechanism is given.
Nikolaev, Anton E.,Semenov, Vyacheslav E.,Sharafutdinova, Dilyara R.,Efremov, Yurii Ya.,Reznik, Vladimir S.
supporting information; body text
p. 5994 - 5997
(2009/04/11)
Aryl pyrimidyl compounds, pharmaceutical compositions comprising them, their use as antimicrobial agents
Molecule responding to formula (I): and its use for the preparation of a medicament for the prevention and/or treatment of a pathology caused by a mycobacteria
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Page/Page column 10
(2010/11/08)
Pyrimidinedione derivatives useful as alpha 1A adrenoceptor antagonists
Novel pyrimidinedione compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1aadrenergic receptor antagonists is also described. One application of these compounds is in the treatmen
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(2008/06/13)
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