57712-67-1Relevant articles and documents
The evaluation of 5-amino- and 5-hydroxyuracil derivatives as potential quadruplex-forming agents
Paragi, Gábor,Kupihár, Zoltán,Endre, Gábor,Fonseca Guerra, Célia,Kovács, Lajos
, p. 2174 - 2184 (2017/03/17)
5-Substituted uracils (NH2 or OH groups in position 5) have been examined theoretically and experimentally as potential building blocks in quadruplex structures. Our high level Density Functional Theory (DFT) calculations showed that the tetram
Macrocyclic 5-bromouracil derivatives: synthesis and transformation of a uracil ring
Nikolaev, Anton E.,Semenov, Vyacheslav E.,Sharafutdinova, Dilyara R.,Efremov, Yurii Ya.,Reznik, Vladimir S.
supporting information; body text, p. 5994 - 5997 (2009/04/11)
Cyclization of 1,3-bis(ω-bromoalkyl)-5-bromouracil with p-methoxybenzylamine or sodium sulfide led to a series of pyrimidinophanes containing heteroatoms in bridges. An unusual behaviour of the 5-bromouracil ring, namely its contraction into hydantoin units during the cyclization reactions with p-methoxybenzylamine was observed. Sodium sulfide does not affect the 5-bromouracil ring, and no transformation products were observed in the synthesis of pyrimidinophanes with sulfur bridges. A possible reaction mechanism is given.
Pyrimidinedione derivatives useful as alpha 1A adrenoceptor antagonists
-
, (2008/06/13)
Novel pyrimidinedione compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1aadrenergic receptor antagonists is also described. One application of these compounds is in the treatmen
