- NOVEL BICYCLIC HETEROCYCLIC COMPOUND
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Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.
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Paragraph 0600; 0601
(2018/09/27)
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- PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS
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This invention relates to imidazopyridylmethylene substituted piperidine derivatives orexin antagonists and their use as pharmaceuticals.
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Page/Page column 33
(2010/07/09)
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- Synthesis of two potential heterocyclic amine food mutagens
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(Chemical Equation Presented) The syntheses of two potential food mutagens formed during cooking, 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-b]pyridine (1) and 2-amino-3,6,7-trimethyl-3H-imidazo[4,5-c]pyridine (2), are described.
- Tanga, Mary J.,Kozocas, Joseph A.,Tochimoto, Todd K.
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p. 661 - 665
(2008/09/21)
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- MODULATORS OF CFTR
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Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.
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- Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
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A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.
- Hagmann,Caldwell,Chen,Durette,Esser,Lanza,Kopka,Guthikonda,Shah,MacCoss,Chabin,Fletcher,Grant,Green,Humes,Kelly,Luell,Meurer,Moore,Pacholok,Pavia,Williams,Wong
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p. 1975 - 1978
(2007/10/03)
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- Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
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Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. STR1
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- Preparation of 4-substituted pyridines using quaternary pyridine salts
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A process for preparing a 4-substituted pyridine product from a starting pyridine substituted in the 4-position by a leaving group susceptible to nucleophilic displacement when the starting pyridine is in quaternized form, comprises, quaternizing the starting pyridine under effective acidic conditions with acrylamide, N-monoalkylacrylamide or N-dialkylacrylamide, subjecting the resultant, corresponding quaternized starting pyridine, to a nucleophilic displacement reaction with a reagent which reacts with it to produce the corresponding quaternary salt of the 4-substituted pyridine product, and dequaternizing the latter under effective basic conditions to liberate the 4-substituted pyridine product.
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- Metal-Chelating 1,3-bis(2'-Pyridylimino)isoindolines
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A variety of novel chelating 1,3-bis(2'-pyridylimino)isoindoline ligands were prepared and characterized including ligands substituted on both the pyridyl and isoindoline ring systems.Noteworthy are the first isoindoline ligands with solubility in aqueous media.A convenient preparation of 4-alkoxyphthalonitriles is reported; these compounds are readily obtained from 4-nitrophthalonitrile and are suitable starting materials for alkoxy-substituted ligands.
- Siegl, Walter O.
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p. 1613 - 1618
(2007/10/02)
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