- Application of 2,2,2-trichloroethoxycarbonyl protection to aminoacridines
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The 2,2,2-trichloroethoxycarbonyl (Troc) group has been successfully used as a protecting group for aminoacridines. Unlike aliphatic amines, deprotection of these aromatic amines yields significant amounts (12-29%) of stable 2,2-dichloroethoxycarbonyl (Dioc) by-products. Formation of bis-carbamates, through the introduction of butoxycarbonyl (Boc) moieties as temporary protecting groups, efficiently solves this problem. Georg Thieme Verlag Stuttgart.
- Zeghida, Walid,Demeunynck, Martine
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