58351-19-2Relevant articles and documents
Alternative products in one-pot reaction of benzylidene-malononitrile, thiocarbamoylacetamide and halomethyl ketones
Krauze,Vijums,Sile,Duburs
experimental part, p. 239 - 244 (2010/07/10)
6-Oxo-5-(1,3-thiazol-2-yl)-1,4,5,6-tetrahydropyridine-3-carbonitriles 17, corresponding 6-oxo-5-(1,3-thiazol-2-yl)-5,6-dihydropyridine-3-carbonitriles 18 and intermediates - 2-(1,3-thiazol-2-yl)acetamides 15 and 4,4-dicyano-2-(1,3- thiazol-2-yl)-butyramides 16 have been obtained as alternative products to 3-hydroxy-2,3-dihydro-7H-thiazolo[3,2-a]pyridines 5 carrying out one-pot condensation of 2-thiocarbamoylacetamide 2, base 3, halomethyl ketones 4 and benzylidenemalononitrile 1.
Reactions with Monothiomalonamides: Synthesis of Polysubstituted Thiazoles
El-Reedy, A. M.,Hussain, S. M.,Youssef, M. M. M.
, p. 521 - 529 (2007/10/02)
Monothiomalonamides (1a, b) coupled with arenediazonium salts yield the α-arylhydrazone derivatives (2a-e).Reaction of 1a, b with α-haloketones afforded polysubstituted thiazoles 6a-e.Compounds 6 condensed with p-nitrosodimethylaniline and coupled with ar