583860-52-0

Basic information

• Product Name: 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone
• Synonyms: ethanone, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-
• CAS NO: 583860-52-0
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 583860-52-0.mol

Chemical Properties

• Boiling Point: 374.4°C at 760 mmHg
• Flash Point: 153.5°C
• Density: 1.317g/cm³
• Vapor Pressure: 2.85E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone(583860-52-0)
• EPA Substance Registry System: 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone(583860-52-0)

Safety Data

• Hazardous Substances Data: 583860-52-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and medications. Its versatile structure allows for the creation of a wide range of pharmaceutical compounds, contributing to the development of new and improved treatments.
Used in Research Chemicals:
In the field of chemical research, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone serves as a key component in the development of research chemicals. Its unique properties make it an essential tool for scientists and researchers working on the discovery and understanding of new chemical compounds and their potential applications.
Used as a Reagent in Organic Synthesis:
Due to its distinctive structure and reactivity, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone is also utilized as a reagent in organic synthesis. It plays a crucial role in the production of various organic compounds, further expanding its applications across different industries.
Safety and Handling:
Given its potential hazards, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxyethanone should be handled and stored in a controlled environment. It is essential that only qualified individuals work with this chemical, following proper safety protocols to ensure the safety of both the personnel and the environment.

Upstream product

• 2879-20-1 1,4-benzodioxan-6-yl methyl ketone 
• 4629-54-3 2-bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone 

Downstream Products

• 18212-83-4 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylethanone 

Relevant articles and documents

Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X

Cathepsin X is a cysteine carboxypeptidase that is involved in various physiological and pathological processes. In particular, highly elevated expression and activity of cathepsin X has been observed in cancers and neurodegenerative diseases. Previously, we identified compound Z9 (1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((4-isopropyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one) as a potent and specific reversible cathepsin X inhibitor. Here, we have explored the effects of chemical variations to Z9 of either benzodioxine or triazol moieties, and the importance of the central ketomethylenethio linker. The ketomethylenethio linker was crucial for cathepsin X inhibition, whereas changes of the triazole heterocycle did not alter the inhibitory potencies to a greater extent. Replacement of benzodioxine moiety with substituted benzenes reduced cathepsin X inhibition. Overall, several synthesized compounds showed similar or improved inhibitory potencies against cathepsin X compared to Z9, with IC50 values of 7.1 μM–13.6 μM. Additionally, 25 inhibited prostate cancer cell migration by 21%, which is under the control of cathepsin X.