- HETEROCYCLIC COMPOUNDS AND USES THEREOF
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Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, lI-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).
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Paragraph 0394
(2021/07/31)
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- Synthetic method of 3-methoxymethylpyridine
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The invention relates to the field of organic chemistry, in particular to a synthetic method of 3-methoxymethylpyridine. The synthetic method comprises the following steps: using 3-methylpyridine as a raw material, and carrying out bromination reaction to obtain 3-bromo-methylpyridine; reacting the 3-bromo-methylpyridine with trimethylamine to obtain (3-picolyl) trimethyl ammonium bromide; dissolving the (3-picolyl) trimethyl ammonium bromide into methanol, then adding sodium methylate, and carrying out heating reflux in the presence of nitrogen for 1 hour to obtain the 3-methoxymethylpyridine. By adopting the synthetic method disclosed by the invention, the 3-methylpyridine is used as the raw material and is subjected to the bromination reaction to obtain the 3-bromo-methylpyridine; the 3-bromo-methylpyridine reacts with the trimethylamine to obtain the (3-picolyl) trimethyl ammonium bromide; finally, the (3-picolyl) trimethyl ammonium bromide reacts with the sodium methoxide to obtain the 3-methoxymethylpyridine. The synthetic method disclosed by the invention has the advantages of high total yield, low price of raw materials, short reaction time, mild conditions and simple process operation.
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Paragraph 0023; 0026; 0028; 0029; 0032; 0033; 0036
(2017/09/29)
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- Merging Photoredox with Br?nsted Acid Catalysis: The Cross-Dehydrogenative C?O Coupling for sp3 C?H Bond Peroxidation
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A photoredox and Br?nsted acid synergistically catalyzed cross-dehydrogenative C?O coupling reaction is developed in which isochroman peroxyacetals are formed through sp3 C?H bond peroxidation. The reported method is characterized by its extremely mild reaction conditions, excellent yields, and broad substrate scope. An oxocarbenium ion p-chlorobenzenesulfonate was speculated to be the reactive intermediate. The role of hemiacetals and oxygenated dimers on the effective stabilization of the oxocarbenium ion was investigated; the presence of acid appeared to establish equilibrium between hemiacetals and oxygenated dimers with the oxocarbenium ion pairs. The broad applicability of the method highlights the potential of the protocol for molecule synthesis.
- Xia, Qing,Wang, Qiang,Yan, Changcun,Dong, Jianyang,Song, Hongjian,Li, Ling,Liu, Yuxiu,Wang, Qingmin,Liu, Xiangming,Song, Haibin
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supporting information
p. 10871 - 10877
(2017/08/18)
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- Grignard reactions in pyridinium and phosphonium ionic liquids
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Alkylpyridinium (10a, R = Me and 10b, R = Et) and tetraalkylphosphonium (19) ionic liquids which possess ether functionality were prepared and evaluated as solvents and co-solvents for Grignard reactions. Interestingly, reduction of the starting aldehydes to the corresponding primary alcohol was the favored pathway when reactions were conducted in pyridinium ILs 10a, b in the absence an ethereal co-solvent. However, the same reactions in the phosphonium IL 19 afforded the expected Grignard products in good yield in cases where diethyl ether was present as a co-solvent.
- Ford, Leigh,Atefi, Farzad,Singer, Robert D.,Scammells, Peter J.
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experimental part
p. 942 - 950
(2011/04/22)
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- HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND
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Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.
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Page/Page column 142
(2011/02/18)
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- HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND
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Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.
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Page/Page column 91
(2011/04/13)
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- COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a neonicotinoid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a neonicotinoid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
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Page/Page column 237
(2011/04/25)
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- COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and pyriproxyfen; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and pyriproxyfen to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
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Page/Page column 236-237
(2011/05/06)
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- COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a pyrethroid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a pyrethroid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
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Page/Page column 237-238
(2011/05/06)
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- COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and pyridalyl; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and pyridalyl to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
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Page/Page column 236
(2011/05/06)
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- COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a diamide compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a diamide compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
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Page/Page column 240-241
(2011/05/06)
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- Further studies on the biodegradation of ionic liquids
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A range of ionic liquids (ILs) containing a pyridinium cation were synthesised and their biodegradability was evaluated using the CO2 headspace test (ISO 14593). ILs bearing a 1-(2-hydroxyethyl) side chain were prepared from either pyridine or nicotinic acid derivatives. These ILs showed high levels of biodegradation under aerobic conditions and can be classified as 'readily biodegradable'. In contrast, pyridinium ILs with methyl or ethyl ether side chains showed significantly lower levels of biodegradability in the same test. Biodegradation studies on a range of novel ILs with acetal and carbamate functionalities, as well as thiazolium-based salts, also showed low levels of mineralization.
- Ford, Leigh,Harjani, Jitendra R.,Atefi, Farzad,Garcia, M. Teresa,Singer, Robert D.,Scammells, Peter J.
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experimental part
p. 1783 - 1789
(2011/01/12)
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- Substituted tetrahydropyridine derivatives acting on 5-HT receptors
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PCT No. PCT/GB96/02763 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Nov. 13, 1996 PCT Pub. No. WO97/18204 PCT Pub. Date May 22, 1997Compounds having formula I, or salts or prodrugs thereof: are selective agonists of the 5-HT1D alpha receptor and are useful in the treatment of migraine and associated conditions.
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