58418-62-5Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS AND USES THEREOF
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Paragraph 0394, (2021/07/31)
Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, lI-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).
Merging Photoredox with Br?nsted Acid Catalysis: The Cross-Dehydrogenative C?O Coupling for sp3 C?H Bond Peroxidation
Xia, Qing,Wang, Qiang,Yan, Changcun,Dong, Jianyang,Song, Hongjian,Li, Ling,Liu, Yuxiu,Wang, Qingmin,Liu, Xiangming,Song, Haibin
supporting information, p. 10871 - 10877 (2017/08/18)
A photoredox and Br?nsted acid synergistically catalyzed cross-dehydrogenative C?O coupling reaction is developed in which isochroman peroxyacetals are formed through sp3 C?H bond peroxidation. The reported method is characterized by its extremely mild reaction conditions, excellent yields, and broad substrate scope. An oxocarbenium ion p-chlorobenzenesulfonate was speculated to be the reactive intermediate. The role of hemiacetals and oxygenated dimers on the effective stabilization of the oxocarbenium ion was investigated; the presence of acid appeared to establish equilibrium between hemiacetals and oxygenated dimers with the oxocarbenium ion pairs. The broad applicability of the method highlights the potential of the protocol for molecule synthesis.
Synthetic method of 3-methoxymethylpyridine
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Paragraph 0023; 0026; 0028; 0029; 0032; 0033; 0036, (2017/09/29)
The invention relates to the field of organic chemistry, in particular to a synthetic method of 3-methoxymethylpyridine. The synthetic method comprises the following steps: using 3-methylpyridine as a raw material, and carrying out bromination reaction to obtain 3-bromo-methylpyridine; reacting the 3-bromo-methylpyridine with trimethylamine to obtain (3-picolyl) trimethyl ammonium bromide; dissolving the (3-picolyl) trimethyl ammonium bromide into methanol, then adding sodium methylate, and carrying out heating reflux in the presence of nitrogen for 1 hour to obtain the 3-methoxymethylpyridine. By adopting the synthetic method disclosed by the invention, the 3-methylpyridine is used as the raw material and is subjected to the bromination reaction to obtain the 3-bromo-methylpyridine; the 3-bromo-methylpyridine reacts with the trimethylamine to obtain the (3-picolyl) trimethyl ammonium bromide; finally, the (3-picolyl) trimethyl ammonium bromide reacts with the sodium methoxide to obtain the 3-methoxymethylpyridine. The synthetic method disclosed by the invention has the advantages of high total yield, low price of raw materials, short reaction time, mild conditions and simple process operation.
HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND
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Page/Page column 142, (2011/02/18)
Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.
HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND
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Page/Page column 91, (2011/04/13)
Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a nitrogen atom or the like; R1 and R4 independently represent a halogen atom or the like; R2 and R3 independently represent a halogen atom or the like; R5 and R6 independently represent a linear C1-C6 hydrocarbon group which may be substituted, or the like (provided that both R5 and R6 cannot represent a hydrogen atom simultaneously); and n represents 0 or 1]. The harmful arthropod control composition has an excellent efficacy to control harmful arthropods.
COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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Page/Page column 237, (2011/04/25)
The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a neonicotinoid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a neonicotinoid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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Page/Page column 236-237, (2011/05/06)
The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and pyriproxyfen; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and pyriproxyfen to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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Page/Page column 237-238, (2011/05/06)
The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a pyrethroid compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a pyrethroid compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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Page/Page column 236, (2011/05/06)
The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and pyridalyl; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and pyridalyl to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS
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Page/Page column 240-241, (2011/05/06)
The present invention provides: an arthropod pests control composition comprising, as active ingredients, a condensed heterocyclic compound and a diamide compound; a method for controlling arthropod pests which comprises applying effective amounts of a condensed heterocyclic compound and a diamide compound to the arthropod pests or a locus where the arthropod pests inhabit; and so on.
