- 3′-Hydroxy-3,4′-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells
-
Flavonoids are naturally occurring polyphenolic compounds and are among the most promising anticancer agents. A series of flavonols and their 3-methyl ether derivatives were synthesized and assessed for cytotoxicity. It was found that 3′-hydroxy-3,4′-dime
- Estévez-Sarmiento, Francisco,Said, Mercedes,Brouard, Ignacio,León, Francisco,García, Celina,Quintana, José,Estévez, Francisco
-
p. 6060 - 6070
(2017/10/13)
-
- SYNTHESIS OF THREE NATURAL 1,3-DIARYLPROPANES: TWO REVISED STRUCTURES
-
1-(2',4'-dihydroxy-3',5'-dimethylphenyl)-3-(2"-hydroxy-4",5"-methylenedioxyphenyl)-Propane, isolated from Iryanthera coriacea and I. laevis, 1-(2'-hydroxy-4'-methoxy-5'-methylphenyl)-3-(2"-hydroxy-4",5"-methylene-dioxyphenyl)-propane, isolated from I. laevis, and 1-(2'-hydroxy-4'-methoxyphenyl)-3-(3"-hydroxy-4"-methoxyphenyl)-propane, isolated from Virola multinervia, were synthesized by processes which involved catalityc hydrogenation of the appropriate chalcones and Clemmensen reduction of dihydrochalcones.Only the structures of 1,3-diarylpropanes isolated from V. multinervia and I. laevis were revised. - Keywords: Virola multinervia; Iryanthera coriaceae; I. laevis; Myristicaceae; 1,3-diarylpropanes; synthesis; reduction of chalcones and dihydrochalcones.
- Morais, Anselmo A.,Fo, Raimundo Braz,Fraiz, Silas V. Jr
-
p. 239 - 242
(2007/10/02)
-