- One-pot double functionalisation of π-deficient heterocyclic lithium reagents
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Herein, we report an efficient method for the double functionalisation of lithiated halogenopyridines, -pyrazines or -furopyridines through a convenient one-pot electrophilic trapping/nucleophilic substitution sequence.
- Chartoire, Anthony,Comoy, Corinne,Fort, Yves
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- POLYORGANOMETALLIC HETEROCYCLES. 2,6-DILITHIOPYRIDINE
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Metal-halogen exchange between 2,6-diiodo- and 2,6-dibromopyridine and two equivalents of n-butyllithium gives 2,6-dilithiopyridine.On quenching with either carbon dioxide followed by esterification, methanol or dimethyl disulfide the dilithio compound gives a methyl 2,6-pyridinedicarboxylate, pyridine, or 2,6-dithiomethylpyridine, respectively.A convenient procedure for halogen-halogen exchange is also described.
- Newkome, George R.,Roper, Jerry M.
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p. 147 - 153
(2007/10/02)
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