58819-71-9Relevant academic research and scientific papers
One-pot double functionalisation of π-deficient heterocyclic lithium reagents
Chartoire, Anthony,Comoy, Corinne,Fort, Yves
, p. 1839 - 1845 (2011)
Herein, we report an efficient method for the double functionalisation of lithiated halogenopyridines, -pyrazines or -furopyridines through a convenient one-pot electrophilic trapping/nucleophilic substitution sequence.
POLYORGANOMETALLIC HETEROCYCLES. 2,6-DILITHIOPYRIDINE
Newkome, George R.,Roper, Jerry M.
, p. 147 - 153 (2007/10/02)
Metal-halogen exchange between 2,6-diiodo- and 2,6-dibromopyridine and two equivalents of n-butyllithium gives 2,6-dilithiopyridine.On quenching with either carbon dioxide followed by esterification, methanol or dimethyl disulfide the dilithio compound gives a methyl 2,6-pyridinedicarboxylate, pyridine, or 2,6-dithiomethylpyridine, respectively.A convenient procedure for halogen-halogen exchange is also described.
