SINTESI ED ATTIVITA ANTIINFIAMMATORIA DI ALCUNI DERIVATI 1,4-BENZOTIAZINICI
A new series of dihydro-4H-1,4-benzothiazine derivatives was prepared.These compounds were obtained by reductive N-alkylation reaction with sodium borohydride in acetic acid of the corresponding 4H-1,4-benzothiazine.Some of the latter compounds were synthesized by a new synthetic method employing 2-aminobenzenethiol and alkynes as starting material. - Preliminary pharmacological data on the antiinflammatory activity of these compounds by using carrageenin paw edema assay are reported.
Non-stereospecific Ring Expansion Reactions of Benzothiazoline Sulfoxides
The stereochemistry of novel ring expansion of benzothiazoline sulfoxides to benzothiazines by reaction with acetic anhydride was examined.Reaction of trans-3-acetyl-2-ethyl-2-methylbenzothiazoline 1-oxide with acetic anhydride afforded 4-acetyl-3-ethylid
Eliminative Ring Fission of 4-Acyl-2,3-dihydro-4H-1,4-benzothiazines
The behavior of 4-acyl-2,3-dihydro-1,4-benzothiazines 1-11 upon treatment with lithium diisopropylamide (LDA) in THF at -78 deg C has been examined.Very marked differences have been observed.Whereas unsubstituted and monosubstituted derivatives (1-4) read
Babudri, F.,Florio, S.,Indelicati, G.,Trapani, G.
p. 4082 - 4087
(2007/10/02)
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