59095-76-0

Basic information

• Product Name: H-GLY-ALA-OME HCL
• Synonyms: GLYCYL-L-ALANYL-L-METHYL ESTER HYDROCHLORIDE;H-GLY-ALA-OME HCL;GLYCYL-L-ANANYL-L-METHYLESTER HYDROCHLORIDE;(S)-methyl 2-(2-aminoacetamido)propanoate hydrochloride;REF DUPL: H-Gly-Ala-OMe HCl
• CAS NO: 59095-76-0
• Molecular Formula: C₆H₁₃N₂O₃*Cl
• Molecular Weight: 196.63
• Mol File: 59095-76-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: H-GLY-ALA-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLY-ALA-OME HCL(59095-76-0)
• EPA Substance Registry System: H-GLY-ALA-OME HCL(59095-76-0)

Safety Data

• Hazardous Substances Data: 59095-76-0(Hazardous Substances Data)

Usage

Uses

Used in Peptide Synthesis:
H-GLY-ALA-OME HCL is used as a building block for creating longer peptide chains with specific sequences and properties. Its incorporation into peptide synthesis allows for the development of bioactive peptides with targeted functions and improved stability.
Used in Pharmaceutical Industry:
H-GLY-ALA-OME HCL is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties enable the development of novel drugs with potential therapeutic applications.
Used in Research and Development:
H-GLY-ALA-OME HCL serves as a valuable tool in research and development, particularly in the fields of biotechnology and biochemistry. It aids in the exploration of peptide-based therapeutics, drug delivery systems, and the understanding of protein-protein interactions.
Used in Drug Development:
H-GLY-ALA-OME HCL is used in drug development to create new pharmaceutical agents with specific biological activities. Its versatility in peptide synthesis allows for the design of drugs with improved efficacy, selectivity, and reduced side effects.

Upstream product

• 95083-50-4 methyl 2-(2-((t-butoxycarbonyl)amino)-ethanamido)propanoate 
• 67-56-1 methanol 

Downstream Products

• 119973-01-2 (S)-2-Isopropyl-3-((S)-1-methoxycarbonyl-ethyl)-4-oxo-imidazolidine-1-carboxylic acid benzyl ester 
• 119997-05-6 (-)-1-(benzyloxycarbonyl)-2(R)-isopropyl-3-<(S)-methyl(methoxycarbonyl)methyl>imidazolidin-4-one 
• 1072115-70-8 L-N-(4-iodobenzoyl)GlyAlaOMe 
• 1228316-07-1 C₃₃H₅₄N₆O₉ 

Relevant articles and documents

Neighboring Residue Effects: Evidence for Intramolecular Assistance to Racemization or Epimerization of Dipeptide Residues

Dipeptides, their methyl esters, diketopiperazines (DKP), and N-substituted derivatives were racemized at high temperatures (approximately 120 deg C) in aqueous phosphate buffered solutions at pH values close to pH of maximum racemization (approximately 8).The racemization of the dipeptides Ala-Gly and Gly-Ala followed reversible first-order kinetics.The initial rate of racemization of DKP was very fast but soon slowed down, supposedly due to hydrolysis.The resulting rate was similar to that of the dipeptides.Esters of dipeptides followed racemization patterns similar to DKP.The racemization rate constants of the dipeptides studied were shown to be independent of the concentration of the dipeptide and the concentration of buffer.A carboxy-terminal proline residue greatly increased the rate of racemization (epimerization) of the amino-terminal residue.Increasing the basicity of the N-terminal amino acid residue increased the rate of racemization (or epimerization) of the C-terminal residue unless the C-terminal was sterically hindered as the Ile and Val.Decreasing the basicity of the N-terminal amino acid residue decreased racemization or epimerization for nonhindered C-terminal amino acids.These results support the influence of neighboring groups in the racemization or epimerization of dipeptides.DKP formation is a competing reaction allowing racemization or epimerization in dipeptides.Dipeptide racemization or epimerization is proposed to be the result of combination of intramolecular base assistance and DKP formation.

Metal Complexes with Biologically Important Ligands, XXXVII. Peptide Synthesis at Platinum(II) Ions

A series of platinum(II) complexes cis- and trans-Cl2Pt(peptide ester)2 (1-16) has been obtained via peptide synthesis at the free carboxylic group of N-coordinated α-amino acids, using a water-soluble carbodiimide as coupling agent.The amino protecting platinum(II) is removed via substitution of the dipeptide ester by 1,2-bis(diphenylphosphino)ethane or, most advantageously, by hydrogenation with hydrogen.Peptide formation and removal of the platinum(II) proceed practically without racemization.

Structure-taste Relationships of Aspartyl Tripeptide Esters

A series of twenty four analogues of L-α-Asp-Gly-Gly-OMe has been synthesized in relation to structural features of sweet peptides.The rule in the structure-taste relationships of dipeptides is held in the sweet aspartyl tripeptide esters.In order for the