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2-methylthieno[3,2-c]pyridin-4(5H)-one is a heterocyclic chemical compound characterized by a molecular formula of C7H5NOS. It features a thieno[3,2-c]pyridine skeleton, which is a fused ring system consisting of a thiophene and a pyridine ring. 2-methylthieno[3,2-c]pyridin-4(5H)-one is recognized for its potential biological activity and is utilized in various applications across different fields.

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  • 59207-23-7 Structure
  • Basic information

    1. Product Name: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE
    2. Synonyms: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE;2-methyl-5H-thieno[3,2-c]pyridin-4-one;2-Methylthieno[3,2-c]pyridin-4(5H)
    3. CAS NO:59207-23-7
    4. Molecular Formula: C8H7NOS
    5. Molecular Weight: 165.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 59207-23-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 415.8 °C at 760 mmHg
    3. Flash Point: 205.3 °C
    4. Appearance: /
    5. Density: 1.292
    6. Vapor Pressure: 4.01E-07mmHg at 25°C
    7. Refractive Index: 1.616
    8. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 13.00±0.20(Predicted)
    11. CAS DataBase Reference: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE(59207-23-7)
    13. EPA Substance Registry System: 2-METHYLTHIENO[3,2-C]PYRIDIN-4(5H)-ONE(59207-23-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 59207-23-7(Hazardous Substances Data)

59207-23-7 Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-methylthieno[3,2-c]pyridin-4(5H)-one is employed as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and potential biological activity make it a valuable component in the development of new drugs and pesticides.
Used in Organic Chemistry:
In the field of organic chemistry, 2-methylthieno[3,2-c]pyridin-4(5H)-one serves as a building block for the synthesis of more complex molecules. Its versatile structure allows for the creation of a wide range of organic compounds with diverse properties and applications.
Used as a Reagent in Organic Synthesis:
2-methylthieno[3,2-c]pyridin-4(5H)-one is also utilized as a reagent in organic synthesis. It aids in the preparation of various organic compounds, contributing to the advancement of chemical research and the development of new materials and products.

Check Digit Verification of cas no

The CAS Registry Mumber 59207-23-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,0 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 59207-23:
(7*5)+(6*9)+(5*2)+(4*0)+(3*7)+(2*2)+(1*3)=127
127 % 10 = 7
So 59207-23-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NOS/c1-5-4-6-7(11-5)2-3-9-8(6)10/h2-4H,1H3,(H,9,10)

59207-23-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-methyl-5H-thieno[3,2-c]pyridin-4-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59207-23-7 SDS

59207-23-7Relevant articles and documents

3D-printed cartridge system for in-flow photo-oxygenation of 7-aminothienopyridinones

Rastelli, Ettore J.,Yue, Doris,Millard, Caroline,Wipf, Peter

supporting information, (2020/12/29)

A 3D-printed polypropylene (PP) continuous-photoflow cell based on a modular cartridge system was developed for the photo-oxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones, using ambient air as the sole co-reactant. This strategy takes advantage of the versatility of 3D-printing to construct cost-effective meso-scale reactors. In addition to scalability, a short residence time (tR 2 min) in 100-W blue LED light that minimizes the formation of dark, insoluble decomposition products is a tangible benefit of this technology.

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors

Yang, Bin,Vasbinder, Melissa M.,Hird, Alexander W.,Su, Qibin,Wang, Haixia,Yu, Yan,Toader, Dorin,Lyne, Paul D.,Read, Jon A.,Breed, Jason,Ioannidis, Stephanos,Deng, Chun,Grondine, Michael,Degrace, Nancy,Whitston, David,Brassil, Patrick,Janetka, James W.

, p. 1061 - 1073 (2018/02/17)

Checkpoint kinase 1 (CHK1) inhibitors are potential cancer therapeutics that can be utilized for enhancing the efficacy of DNA damaging agents. Multiple small molecule CHK1 inhibitors from different chemical scaffolds have been developed and evaluated in clinical trials in combination with chemotherapeutics and radiation treatment. Scaffold morphing of thiophene carboxamide ureas (TCUs), such as AZD7762 (1) and a related series of triazoloquinolines (TZQs), led to the identification of fused-ring bicyclic CHK1 inhibitors, 7-carboxamide thienopyridines (7-CTPs), and 7-carboxamide indoles. X-ray crystal structures reveal a key intramolecular noncovalent sulfur-oxygen interaction in aligning the hinge-binding carboxamide group to the thienopyridine core in a coplanar fashion. An intramolecular hydrogen bond to an indole NH was also effective in locking the carboxamide in the preferred bound conformation to CHK1. Optimization on the 7-CTP series resulted in the identification of lead compound 44, which displayed respectable drug-like properties and good in vitro and in vivo potency.

A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES

-

, (2015/02/25)

Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase- mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo -bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.

Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications

Li, Lingjun,Degardin, Melissa,Lavergne, Thomas,Malyshev, Denis A.,Dhami, Kirandeep,Ordoukhanian, Phillip,Romesberg, Floyd E.

supporting information, p. 826 - 829 (2014/02/14)

We synthesized a panel of unnatural base pairs whose pairing depends on hydrophobic and packing forces and identify dTPT3-dNaM, which is PCR amplified with a natural base pair-like efficiency and fidelity. In addition, the dTPT3 scaffold is uniquely tolerant of attaching a propargyl amine linker, resulting in the dTPT3PA-dNaM pair, which is amplified only slightly less well. The identification of dTPT3 represents significant progress toward developing an unnatural base pair for the in vivo expansion of an organism's genetic alphabet and for a variety of in vitro biotechnology applications where it is used to site-specifically label amplified DNA, and it also demonstrates for the first time that hydrophobic and packing forces are sufficient to mediate natural-like replication.

Design and synthesis of piperazinylpyridine derivatives as novel 5-HT 1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS)

Asagarasu, Akira,Matsui, Teruaki,Hayashi, Hiroyuki,Tamaoki, Satoru,Yamauchi, Yukinao,Sato, Michitaka

experimental part, p. 34 - 42 (2009/07/18)

We have prepared a series of piperazinylpyridine derivatives for the treatment of irritable bowel syndrome (IBS). These compounds, which were designed by pharmacophore analysis, bind to both serotonin subtype 1A (5-HT 1A) and subtype 3 (5-HT3) receptors. The nitrogen atom of the isoquinoline, a methoxy group and piper-azine were essential to the pharmacophore for binding to these receptors. We also synthesized furo- and thienopyridine derivatives according to structure-activity relationship analyses. Compound 17c (TZB-20810) had high affinities to these receptors and exhibited 5-HT1A agonistic activity and 5-HT3 antagonistic activity concurrently, and is a promising drug for further development in the treatment of IBS.

SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS

-

, (2008/06/13)

This invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are accordingly useful in the treatment and/or prophylaxis of cancer.

Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds

-

, (2008/06/13)

The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, for treating a patient suffering from, or subject to, a physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

1-SUBSTITUTED AMINO-3-THIENO-[3,2-c]PYRIDINYLOXY-2-PROPANOLS

-

, (2008/06/13)

This invention provides new compounds of formula I, STR1 wherein X is sulphur or oxygen,R is alkyl of 3 to 7 carbon atoms or cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubstituted by alkyl of 1 to 4 carbon atoms, α-dialkylpropinyl of 5 to 9 carbon atoms or α-dialkyl-allyl of 5 to 9 carbon atoms, hydroxyalkyl of 2 to 7 carbon atoms or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the last two radicals being separated by at least two carbon atoms from the nitrogen atom to which R is bound, R 1 isI. hydrogen or alkyl of 1 to 4 carbon atoms in the 2,3,6 or 7 position, orIi. chlorine or bromine, in the 2, 3 or 7 position,Iii. nitro or--NHA wherein A is alkanoyl of 1 to 4 carbon atoms, in the 2, 3 or 7 position, orIv. fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position, andR 2 isI. hydrogen or alkyl of 1 to 4 carbon atoms in the 2, 3, 6 or 7 position,Ii. chlorine or bromine, in the 2, 3 or 7 position, orIii. fluorine in the 2 or 3 position,Useful in the treatment of heart diseases.

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