Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions
The binding affinity of 4, which incorporates a methylene (CH2) in place of the key linking amide of Ac2-L-Lys-d-Ala-d-Ala, for vancomycin was compared with that of Ac2-L-Lys-d-Ala-d-Ala (3) and Ac2-L-Lys-d-Ala-
McComas, Casey C.,Crowley, Brendan M.,Boger, Dale L.
Get Best Price for593278-49-0Hexanoic acid,
5-[[(2S)-2,6-bis[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxohexyl]amino]
-2-methyl-4-oxo-, phenylmethyl ester, (2S,5R)-