- Preparation method of sorbitan oleate
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The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of sorbitan oleate. The preparation method comprises: adding a catalyst I, dehydrating solid sorbitol powder to obtain 1,4-sorbitan, adding oleic acid and a catalyst II, and carrying out an esterification reaction of oleic acid and 1,4-sorbitan to obtain sorbitan oleate to obtain sorbitan oleate. According to the method, the phenomenon that sediment is generated during storage of sorbitan oleate is prevented, the appearance and color of sorbitan oleate is prevented, and the exterior quality is effectively improved. Sorbitan oleate obtained from the method is good in emulsifying property and stability, and the application range of sorbitan oleate is extended.
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Paragraph 0027; 0029; 0030; 0032; 0033; 0035; 0036; 0038
(2017/04/13)
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- COMBINATION COMPOSITION COMPRISING BENZOYL PEROXIDE AND ADAPALENE
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An aqueous gel composition of the present invention comprising about 0.1 to 0.3 wt % adapalene and about 2.5 to 5.0 wt % benzoyl peroxide, as active ingredients, wherein both the active ingredients are stabilized in hydrophilic gelling matrix of pH dependent gelling agent comprising crosslinked, acrylic acid-based polymer(s).
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- PROCESS FOR PRODUCING POLYOXYETHYLENE SORBITAN FATTY ACID ESTER
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An object of the present invention is to provide a process for producing a polyoxyethylene sorbitan fatty acid ester in which the bitterness just after the production is suppressed and also an increase in the bitterness with the lapse of time is suppressed. The process for producing a polyoxyethylene sorbitan fatty acid ester of the invention includes reacting an ester (component A) of a fatty acid having 10 to 22 carbon atoms and a monohydric alcohol having 1 to 3 carbon atoms with at least either (component B) of sorbitol and sorbitan to form a sorbitan fatty acid ester and adding ethylene oxide to the sorbitan fatty acid ester, thereby producing a polyoxyethylene sorbitan fatty acid ester, which is characterized that the following steps (a) to (d) are contained: (a) the component B is provided in the form of a 50 to 90% by weight aqueous solution and mixed with the component A and dehydration was performed until a water content in the system reaches 1.0% by weight or less based on the total weight of the components A and B; (b) 1 to 10% by weight of a monohydric alcohol having 1 to 3 carbon atoms and 0.1 to 1.0% by weight of an alkali catalyst based on the total weight of the components A and B are added at 50 to 90° C.; (c) a transesterification reaction is performed under a nitrogen stream at a reaction temperature of 140 to 190° C. to thereby obtain a sorbitan fatty acid ester; (d) ethylene oxide is added thereto at a reaction temperature of 70 to 130° C.
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Page/Page column 5
(2010/12/29)
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- Novel pharmaceutical composition of ceftiofur
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The present invention relates to a pharmaceutical oily suspension comprising cephalosporin antibiotic or its pharmaceutically acceptable salt, at least a biocompatible oil, a wetting agent, a dispersing agent and a resuspendibility enhancer, said suspension has improved properties, such as resuspendibility and chemical stability and process thereof.
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- Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size
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Microparticles such as propagules of eukaryotic biocontrol agents are encapsulated in cellular-scale polymer capsules that have a diameter similar to normal eukaryotic cells in a range of about 10 μm to about 400 μm. The microparticles are encapsulated by adding a hydrophobic dispersion medium such as a mixture of chloroform and hexane or a mixture of corn oil and n-hexadecane having a specific gravity of about 1 and containing an emulsifier such as lecithin to an aqueous suspension of the microparticles and a polymer matrix precursor such as alginate, agitating vigorously to form a stable emulsion of microscopic globules containing a microparticle, and adding the emulsion to an aqueous solution containing a polymerizing agent such as calcium chloride to polymerize and precipitate the globules to form microparticles encapsulated in polymer matrix capsules that may be of a teardrop shape having a length of 40-200% longer than the diameter. Precipitation of the globules is regulated by substantially matching the Specific Gravity of the hydrophobic dispersion medium and the aqueous suspension. The microparticle may be a viable propagule of a weed pathogenic fungus to provide a herbicidal composition.
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- Phospholipid-and cholestrol-free aqueous composition for topical application to the skin
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Phospholipid- and cholesterol-free aqueous compositions for topical application to the skin contain a pharmaceutically active ingredient and a vector system of controlled and in-depth transport and release of the active ingredient through the skin. The vector system comprises at least one first non-ionic surfactant which forms vesicles upon dispersion in water and a lamellar phase upon concentrating the vesicles, and at least one second non-ionic hydrophilic surfactant. The ratios of the two non-ionic surfactants are such that the vector system comprises flexible vesicles.
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- Water-based pesticidal composition
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A water-based pesticidal composition contains 100 weight parts of substantially water-insoluble pesticide and 1.7-200 weight parts of a surface active agent. The surface active agent contains Component A and Component B at weight ratio of A/B=80/20-20/80. Component A is polyalkylene glycol ether derivative of polyethylene polyamine shown by the following general formula and having molecular weight of 20,000-100,000: STR1 where R1, R2, R3 and R4 are selected from the group consisting of hydrogen, alkyl group with 1-4 carbon atoms, alkanoyl group with 2-18 carbon atoms, alkenoyl group with 2-18 carbon atoms and polyoxyalkylene glycol group containing oxyethyne unit and oxypropylene unit at weight ratio of (oxyethyne unit/oxypropylene unit=)100/0-50/50, at least one of R1, R2, R3 and R4 being the polyoxyalkylene glycol group, and n is an integer 2-250. Component B includes one or more selected from the group consisting of partial esters of polyhydric alcohol selected from sorbitol, sorbitan, glycerine and polyglycerine and unsaturated aliphatic acid with 16-22 carbon atoms and ethylene oxide adducts of such partial esters.
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- Microencapsulated agriculturally active material
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Agriculturally active materials, such as pesticides, herbicides and the like and a process for microencapsulating said material. The present invention includes trifluralin having a polymorphic form characterized by a yellow color and a melting point of approximately 41°-43° C. The present invention also includes a method using the yellow polymorphic form of trifluralin as a herbicide. In addition, the present invention includes a method of microencapsulating low-melting agriculturally active materials, such as trifluralin. The microencapsulation process comprises the steps of heating a low-melting, water-immiscible, agriculturally active material to a molten state. The molten active material is then combined with an aqueous solution of a water-soluble, film-forming polymer at a temperature sufficient to maintain the active material in its molten state. The active material is then dispersed or emulsified in the aqueous solution so that the active material has a primary particle size of between approximately 0.1 and 10 microns. The resulting dispersion or emulsion is then spray dried at a temperature between approximately 50° and 220° C. so as to microencapsulate the active material in the polymer. Compounds for promoting the rapid solidification of the active material are also disclosed.
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