59410-82-1

Basic information

• Product Name: H-PHG-OET HCL
• Synonyms: PHENYLGLYCINE-OET HCL;L-PHENYLGLYCINE ETHYL ESTER HYDROCHLORIDE;H-PHG-OET HCL;H-Phg-OEt;Ethyl L-Phenylglycine Ester Hydrochloride;(S)-(+)-2-Aminophenylacetic acid ethyl ester hydrochloride;L-Phg-OEt·HCl;Ethyl L-Tryptophanate Hydrochloride,99%e.e.
• CAS NO: 59410-82-1
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.68
• Mol File: 59410-82-1.mol

Chemical Properties

• Melting Point: 202-204 °C
• Boiling Point: 257°C at 760 mmHg
• Flash Point: 120°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 0.0149mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-PHG-OET HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHG-OET HCL(59410-82-1)
• EPA Substance Registry System: H-PHG-OET HCL(59410-82-1)

Safety Data

• Hazardous Substances Data: 59410-82-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
H-PHG-OET HCL is used as a reagent or precursor in chemical synthesis for its reactivity and structural properties, contributing to the development of new compounds and materials.
Used in Pharmaceutical Research:
H-PHG-OET HCL is used as a research compound in pharmaceuticals, potentially aiding in the discovery and development of new drugs due to its unique chemical properties.
Used in Polymer Industry:
H-PHG-OET HCL is used as a precursor or modifier in the polymer industry, where its reactivity may contribute to the creation of novel polymers with specific characteristics.
Used in Other Fields:
H-PHG-OET HCL may have applications in other fields where its chemical properties can be leveraged for specific purposes, such as in the development of new materials or processes.

InChI:InChI=1/C10H13NO2/c1-2-13-10(12)9(11)8-6-4-3-5-7-8/h3-7,9H,2,11H2,1H3/t9-/m0/s1

Upstream product

• 64-17-5 ethanol 
• 2935-35-5 (S)-2-phenylglycine 
• 2835-06-5 phenylglycin 

Downstream Products

• 91757-32-3 3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-[1,2,4]oxadiazin-6-one 
• 129704-13-8 (S)-2-amino-1,1,2-triphenylethanol 
• 2935-35-5 (S)-2-phenylglycine 
• 219323-43-0 (S)-ethyll 2-(benzyloxycarbonylamino)-2-phenylacetate 
• 1859-00-3 N'-(4-methyphenyl)benzamidine 
• 1353639-68-5 C₂₄H₂₇N₆O₁₁P 

Relevant articles and documents

Potent arylamide derivatives as dual-target antifungal agents: Design, synthesis, biological evaluation, and molecular docking studies

Fungal infections have become a serious medical problem due to the high infection rate and the frequent emergence of drug resistance. Ergosterol is an important structural component of the fungal cell membrane, its synthetases (squalene epoxidase (SE) and 14α-demethylase (CYP51)) are considered as the key points to block the ergosterol synthesis. In this study, we designed a series of dual-target arylamides derivatives based on the analysis of active sites (SE, CYP51). Subsequently, these target compounds were synthesized, and their antifungal activity was evaluated. Most of compounds demonstrate the potent antifungal activity against multiple Candida spp. and A. fum. In particular, the antifungal activities of compounds 10b and 11c are not only superior to positive control drugs, but also have significant inhibitory effects on drug-resistant fungi (C.alb. Strain100, C.alb. Strain103). Therefore, their action mechanism was further studied. Cellular uptake and electron microscopy observation showed that target compounds were able to enter fungal cytoplasmic region through free diffusion, and destroyed cell membrane structure. At the same time, preliminary mechanisms have demonstrated that they can affect the synthesis of ergosterol by inhibiting the activity of dual targets. It is worth noting that they also can exhibit excellent antifungal activity and low toxic side effects in vivo. Their ADMET properties and binding models were established will be useful for further lead optimization.

Palladium(II)-catalyzed one-pot enantioselective synthesis of arylglycine derivatives from ethyl glyoxylate, p-toluenesulfonyl isocyanate and arylboronic acids

A palladium(II)-catalyzed, one-pot enantioselective synthesis of arylglycine derivatives from ethyl glyoxylate, p-toluenesulfonyl isocyanate and arylboronic acids giving moderate to good yields and enantioselectivity has been developed. This reaction prov

Asymmetric synthesis of protected arylglycines by rhodium-catalyzed addition of arylboronic acids to N-tert-butanesulfinyl imino esters

A new method for the Rh(I)-catalyzed addition of arylboronic acids to N-tert-butanesulfinyl imino esters has been developed for the asymmetric synthesis of arylglycine derivatives. This method provides high yields (61-90%) and diastereoselectivities (>98:2) for a variety of functionalized arylboronic acids. The N-sulfinyl arylglycine ester products are versatile intermediates for further transformations, including selective protecting group removal, conversion to β-amino alcohols, and direct incorporation into peptides. Copyright

Isozyme-specific glutathione-S-transferase inhibitors: Design and synthesis

Glutathione-S-transferase (GST) isozyme-selective inhibitors were designed by an empirically guided strategy. In the first phase, literature data were used to select C-terminal modifications which generated maximum variation in the catalytic efficiency (V