H-PHG-OET HCL

Base Information

• Chemical Name: H-PHG-OET HCL
• CAS No.: 59410-82-1
• Molecular Formula: C10H13 N O2 . Cl H
• Molecular Weight: 215.68
• Hs Code.: 2922499990
• Mol file: 59410-82-1.mol

Synonyms:Benzeneaceticacid, a-amino-, ethyl ester, hydrochloride,(S)-; Benzeneacetic acid, a-amino-, ethylester, hydrochloride, (aS)- (9CI);(S)-Phenylglycine ethyl ester hydrochloride; L-Phenylglycine ethyl esterhydrochloride; ethyl (2S)-2-amino-2-phenylethanoate hydrochloride

Chemical Property of H-PHG-OET HCL

Chemical Property:

• Vapor Pressure: 0.0149mmHg at 25°C
• Melting Point: 202-204 °C
• PSA: 52.32000
• LogP: 2.75180
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

L-Phenylglycine ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PHG-OET HCL

There total 3 articles about H-PHG-OET HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + (S)-2-phenylglycine (2935-35-5) → (S)-α-phenylglycine ethyl ester hydrochloride (59410-82-1)

Guidance literature:

With thionyl chloride; at 40 ℃;

Reference yield:

(2-methyl-propane-2-sulfinylamino)-phenyl-acetic acid ethyl ester → (S)-α-phenylglycine ethyl ester hydrochloride (59410-82-1) + (R)-2-phenylglycine ethyl ester hydrochloride (17609-48-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; Title compound not separated from byproducts;

DOI:10.1021/ja060529h

Reference yield:

phenylglycin (2835-06-5) → (S)-α-phenylglycine ethyl ester hydrochloride (59410-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: camphor-β-sulfonic acid

2: hydrochloric acid

With hydrogenchloride; (1S)-10-camphorsulfonic acid;

upstream raw materials:

ethanol

(S)-2-phenylglycine

phenylglycin

Downstream raw materials:

(S)-2-amino-1,1,2-triphenylethanol

(S)-2-phenylglycine

Refernces

• 1、 Dai, Huixiong,Yang, Miao,Lu, Xiyan. "Palladium(II)-catalyzed one-pot enantioselective synthesis of arylglycine derivatives from ethyl glyoxylate, p-toluenesulfonyl isocyanate and arylboronic acids". supporting information; experimental part. p. 249 - 253. Retrieved 2009/04/11.
• 2、 Lyttle,Hocker,Hui,Caldwell,Aaron,Engqvist- Goldstein,Flatgaard,Bauer. "Isozyme-specific glutathione-S-transferase inhibitors: Design and synthesis". . p. 189 - 194. Retrieved 2007/10/02.