A photoinducible 1,3-dipolar cycloaddition reaction for rapid, selective modification of tetrazole-containing proteins
(Figure Presented) Reactive but biologically inert: The bioorthogonal title reaction enables highly specific chemical modifications, such as lipidation, of engineered proteins containing a diphenyltetrazole group (see scheme). The cycloaddition in biological media is extremely fast (≤1 min) and tolerant of proteinaceous groups. Strongly fluorescent pyrazoline cycloadducts are generated with simple alkenes.
Song, Wenjiao,Wang, Yizhong,Qu, Jun,Madden, Michael M.,Lin, Qing
supporting information; experimental part
p. 2832 - 2835
(2009/02/06)
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