- 5-Endo-dig electrophilic cyclization of α-alkynyl carbonyl compounds: Synthesis of novel bicyclic 5-iodo- and 5-bromofuranopyrimidine nucleosides
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5-Endo-dig electrophilic cyclization of 5-alkynyl-2′-deoxyuridines with N-iodosuccinimide or N-bromosuccinimide in acetone at room temperature gives 3-(2′-deoxy-β-D-ribofuranosyl)-5-halo-2,3-dihydrofuro[2,3-d] pyrimidin-2-ones that usually precipitate fro
- Srinivasa Rao, Meneni,Esho, Noor,Sergeant, Craig,Dembinski, Roman
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- Metallo-nucleosides: Synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2′-deoxyuridines
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Reactions of 5-alkynyl-2′-deoxyuridines with dicobalt octacarbonyl Co2(CO)8 in THF at room temperature gave hexacarbonyl dicobalt nucleoside complexes (77-93%). The metallo-nucleosides were characterized, including an X-ray structure
- Sergeant, Craig D.,Ott, Ingo,Sniady, Adam,Meneni, Srinivasarao,Gust, Ronald,Rheingold, Arnold L.,Dembinski, Roman
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- 5-Alkynyl-2′-deoxyuridines: Chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells
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Starting with 5-iodo-2′-deoxyuridine, a series of 5-alkynyl-2′-deoxyuridines (with n-propyl, cyclopropyl, 1-hydroxycyclohexyl, p-tolyl, p-tert-butylphenyl, p-pentylphenyl, and trimethylsilyl alkyne substituents) have been synthesized via the palladium-cat
- Meneni, Srinivasarao,Ott, Ingo,Sergeant, Craig D.,Sniady, Adam,Gust, Ronald,Dembinski, Roman
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p. 3082 - 3088
(2008/02/01)
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- Bicyclic nucleoside inhibitors of Varicella-Zoster virus: The effect of branching in the p-alkylphenyl side chain
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Further to the discovery of bicyclic furanopyrimidine nucleoside analogues (BCNAs) as potent anti-VZV agents, a branched series of this family of compounds was synthesised. The aim was to study the impact of the geometry and steric hindrance in the side c
- Luoni, Giovanna,McGuigan, Christopher,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Balzarini, Jan
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p. 3791 - 3796
(2007/10/03)
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