596107-17-4Relevant academic research and scientific papers
5-Endo-dig electrophilic cyclization of α-alkynyl carbonyl compounds: Synthesis of novel bicyclic 5-iodo- and 5-bromofuranopyrimidine nucleosides
Srinivasa Rao, Meneni,Esho, Noor,Sergeant, Craig,Dembinski, Roman
, p. 6788 - 6790 (2003)
5-Endo-dig electrophilic cyclization of 5-alkynyl-2′-deoxyuridines with N-iodosuccinimide or N-bromosuccinimide in acetone at room temperature gives 3-(2′-deoxy-β-D-ribofuranosyl)-5-halo-2,3-dihydrofuro[2,3-d] pyrimidin-2-ones that usually precipitate fro
Metallo-nucleosides: Synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2′-deoxyuridines
Sergeant, Craig D.,Ott, Ingo,Sniady, Adam,Meneni, Srinivasarao,Gust, Ronald,Rheingold, Arnold L.,Dembinski, Roman
, p. 73 - 80 (2008/09/20)
Reactions of 5-alkynyl-2′-deoxyuridines with dicobalt octacarbonyl Co2(CO)8 in THF at room temperature gave hexacarbonyl dicobalt nucleoside complexes (77-93%). The metallo-nucleosides were characterized, including an X-ray structure
5-Alkynyl-2′-deoxyuridines: Chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells
Meneni, Srinivasarao,Ott, Ingo,Sergeant, Craig D.,Sniady, Adam,Gust, Ronald,Dembinski, Roman
, p. 3082 - 3088 (2008/02/01)
Starting with 5-iodo-2′-deoxyuridine, a series of 5-alkynyl-2′-deoxyuridines (with n-propyl, cyclopropyl, 1-hydroxycyclohexyl, p-tolyl, p-tert-butylphenyl, p-pentylphenyl, and trimethylsilyl alkyne substituents) have been synthesized via the palladium-cat
Bicyclic nucleoside inhibitors of Varicella-Zoster virus: The effect of branching in the p-alkylphenyl side chain
Luoni, Giovanna,McGuigan, Christopher,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Balzarini, Jan
, p. 3791 - 3796 (2007/10/03)
Further to the discovery of bicyclic furanopyrimidine nucleoside analogues (BCNAs) as potent anti-VZV agents, a branched series of this family of compounds was synthesised. The aim was to study the impact of the geometry and steric hindrance in the side c
