597528-07-9

Basic information

• Product Name: 5-(BROMOMETHYLENE)IMIDAZOLIDINE-2,4-DIONE
• Synonyms: 5-(BROMOMETHYLENE)IMIDAZOLIDINE-2,4-DIONE
• CAS NO: 597528-07-9
• Molecular Formula: C₄H₃BrN₂O₂
• Molecular Weight: 190.98
• Mol File: 597528-07-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(BROMOMETHYLENE)IMIDAZOLIDINE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(BROMOMETHYLENE)IMIDAZOLIDINE-2,4-DIONE(597528-07-9)
• EPA Substance Registry System: 5-(BROMOMETHYLENE)IMIDAZOLIDINE-2,4-DIONE(597528-07-9)

Safety Data

• Hazardous Substances Data: 597528-07-9(Hazardous Substances Data)

Upstream product

• 1113-59-3 bromopyruvic acid 
• 57-13-6 urea 

Relevant articles and documents

HEADGROUP LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS

The application relates to lipids of Formula (A-1) and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include such a lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/ or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

Syntheses, addition-eliminations, and addition-displacements of 5-(bromomethylene)hydantoins

5-(Bromomethylene)hydantoins, prepared from bromopyruvic acid and ureas in the presence of BF3, react with various nitrogen, phosphorus, sulfur, and carbon nucleophiles by addition-elimination to give the corresponding 5-(substituted-methylene)hydantoins. The 5-(bromomethylene)hydantoins also undergo acid-catalyzed reactions with nucleophiles by addition-displacement and addition-elimination processes.