- Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes
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Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.
- Chen, Xuenian,Kang, Jia-Xin,Ma, Yan-Na,Miao, Yu-Qi
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supporting information
p. 3595 - 3599
(2021/06/06)
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- Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation
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There is a strong incentive for environmentally benign and sustainable production of organic nitriles to avoid the use of toxic cyanides. Here we report that manganese oxide nanorod-supported single-site Ru catalysts are active, selective, and stable for oxidative cyanation of various alcohols to give the corresponding nitriles with molecular oxygen and ammonia as the reactants. The very low amount of Ru (0.1 wt %) with atomic dispersion boosts the catalytic performance of manganese oxides. Experimental and theoretical results show how the Ru sites enhance the ammonia resistance of the catalyst, bolstering its performance in alcohol dehydrogenation and oxygen activation, the key steps in the oxidative cyanation. This investigation demonstrates the high efficiency of a single-site Ru catalyst for nitrile production.
- Gates, Bruce C.,Guan, Erjia,Meng, Xiangju,Wang, Chengtao,Wang, Hai,Wang, Liang,Wang, Sai,Xiao, Feng-Shou,Xu, Dongyang,Xu, Hua,Yang, Bo,Zhang, Jian
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p. 6299 - 6308
(2020/07/21)
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- Base-Mediated Amination of Alcohols Using Amidines
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Novel and efficient base-mediated N-alkylation and amidation of amidines with alcohols have been developed, which can be carried out in one-pot reaction conditions, which allows for the synthesis of a wide range of N-alkyl amines and free amides in good to excellent yields with high atom economy. In contrast to borrowing hydrogen/hydrogen autotransfer or oxidative-type N-alkylation reactions, in which alcohols are activated by transition-metal-catalyzed or oxidative aerobic dehydrogenation, the use of amidines provides an effective surrogate of amines. This circumvents the inherent necessity in N-alkylation of an oxidant or a catalyst to be stabilized by ligands.
- Chen, Jianbin,Fang, Yanchen,Jia, Xiaofei,Jiang, Shaohua,Li, Zehua,Liang, Zuyu,Lu, Fenghong,Qi, Shuo,Ren, Chaoyu,Yu, Shuangming,Zhang, Chunyan,Zhang, Guoying,Zhang, Sheng
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p. 7728 - 7738
(2020/07/15)
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- Triazole urease inhibitor type feed additive and preparation method thereof
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The invention discloses a triazole urease inhibitor type feed additive and a preparation method thereof and belongs to the technical field of synthesis of feed additives. According to the technical scheme, a structural formula of the triazole urease inhibitor type feed additive is shown in the description. The invention further discloses the preparation method of the triazole urease inhibitor typefeed additive. The triazole urease inhibitor type feed additive prepared by the preparation method can be used as non-protein nitrogen and has a certain inhibition effect on urease; the triazole urease inhibitor type feed additive has the effects of sterilizing and resisting ulcer and has a potential of being used as an excellent animal feed additive.
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Paragraph 0024-0029
(2019/02/04)
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- Tetrazole urease inhibitor type feed additive and preparation method thereof
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The invention discloses a tetrazole urease inhibitor type feed additive and a preparation method thereof and belongs to the technical field of synthesis of feed additives. According to the technical scheme, a structural formula of the tetrazole urease inhibitor type feed additive is shown in the description. The invention further discloses the preparation method of the tetrazole urease inhibitor type feed additive. The tetrazole urease inhibitor type feed additive prepared by the preparation method can be used as non-protein nitrogen and has a certain inhibition effect on urease; the tetrazoleurease inhibitor type feed additive has the effects of sterilizing and resisting ulcer and has a potential of being used as an excellent animal feed additive.
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Paragraph 0018; 0024; 0025; 0026; 0027; 0028; 0029
(2019/02/04)
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- A Mild and Convenient Oxidation of Aryl Nitriles to Aryl Amides by Aqueous Sodium Perborate
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A series of benzonitriles has been reacted with sodium perborate in water and a cosolvent to produce the corresponding amides in good yield.The procedure is a mild and convenient alternative for the synthesis of aryl amides.
- Reed, Kathryn L.,Gupton, John T.,Solarz, Traci L.
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p. 563 - 571
(2007/10/02)
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- FURTHER FUNCTIONAL GROUP OXIDATIONS USING SODIUM PERBORATE
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Sodium perborate in acetic acid is an effective reagent for the oxidation of aromatic aldehydes to carboxylic acids, iodoarenes to (diacetoxyiodo)arenes, azines to N-oxides, and various types of sulfur heterocycles to S,S-dioxides.Nitriles are unaffected by the reagent in acetic acid, but undergo smooth hydration to amides when aqueous methanol is employed as solvent.
- McKillop, Alexander,Kemp, Duncan
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p. 3299 - 3306
(2007/10/02)
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