cas 59843-55-9, 3-(2-Chloro-phenyl)-1h-pyrazole | Articles data ｜lookchem

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59843-55-9

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HETEROARYLS AND USES THEREOF
This invention provides compounds of formula IB: and also provides compounds of formulas ID, IIB, VB, and IIC: wherein HY, R1, R2, G5, G6, G7, G8, and G9 are as described in the specification. The compounds are inhibitors of VPS34 and/or PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
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Paragraph 0974

(2013/07/05)

Efficient and simple synthesis of 3-aryl-1H-pyrazoles
Efficient preparation of 3-aryl-1H-pyrazoles by reaction of 1-protected-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoles with (het)aryl halides is described. The choice of THP protecting group is discussed.
Gérard, Anne-Laure,Bouillon, Alexandre,Mahatsekake, Clément,Collot, Valérie,Rault, Sylvain
p. 4665 - 4669
(2007/10/03)

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Chemical Properties

Melting Point: 76-77
Boiling Point: 346 °C at 760 mmHg
Flash Point:193.8 °C
Density: 1.292 g/cm³
Vapor Pressure: 0.000119mmHg at 25°C
Refractive Index: 1.615
PSA: 28.68000
LogP: 2.73010

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