- TRITERPENE GLYCOSIDES OF ALFALFA. IV. MEDICOSIDE J.
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A new triterpene glycoside has been isolated from the roots of Medicago sativa L. (family Fabaceae) - medicoside J, and its structure has been established as a medicagenic acid 3-O-β-D-glucopyranoside 28-O-4)-O-α-L-rhamnopyranosyl-(1->2)-β-L-arabinopyranoside>.
- Timbekova, A. E.,Abubakirov, N. K.
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- Two new compounds from Semen celosiae and their protective effects against CCl4-induced hepatotoxicity
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Two new oleanolic acid saponins, namely celosin A (1) and celosin B (2), together with six known compounds, stigmasterol (3), β-sitosterol (4),-daucosterol (5), hexacosoic acid (6), palmitic acid (7) and stearic acid (8), were isolated from the ethanolic extract of Semen celosiae. The structures of celosin A (1) and celosin B (2) were determined by spectral analysis (including 1D-and 2D-NMR). The hepatoprotective activity of 1 and 2 with oral doses 1.0, 2.0 and 4.0 mg kg-1 were investigated by carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. The results indicate that they have significant hepatoprotective effects, and that these hepatoprotective effects may be due to the antioxidant capability.
- Xue, Qian,Sun, Zhen-Liang,Guo, Mei-Li,Wang, Ying,Zhang, Ge,Wang, Xiao-Kang
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p. 772 - 780
(2011/06/17)
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- TRITERPENE GLYCOSIDES OF ALFALFA
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A new triterpene glycoside - medicoside H - has been isolated from the roots of Medicago sativa L. (Fabaceae), and on the basis of chemical transformations and spectral characteristics its structure has been established as medicagenic acid 3-O-β-D-glucopyranoside 28-O-2)-β-L-arabinopyranoside>.
- Timebekova, A. E.,Larin, M. F.,Yagudaev, M. R.,Abubakirov, N. K.
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p. 573 - 576
(2007/10/02)
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- STRUCTURAL ELUCIDATION OF ALFALFA ROOT SAPONINS BY MASS SPECTROMETRY AND NUCLEAR MAGNETIC RESONANCE ANALYSIS
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Structures of saponins may be fully elucidated using a combination of n.m.r. and m.s. instead of the usual degradation techniques.Well resolved proton n.m.r. spectra and chromatographic separation can be obtained from peracetylated mixtures of saponins.Under these conditions, genins are identified mainly by (13)C n.m.r. spectroscopy; sugars and their points of attachment are determined by examining (1)H chemical shifts and coupling constants following assignments made by 2D COSY and relayed COSY experiments.Sugar chains are sequenced by observing intersugar connectivities through long-range couplings (delayed COSY) or n.O.e.Alternatively, the use of Californium plasma desorption m.s. provides quasimolecular ions and fragments corresponding to the sequential rupture of the chain of sugars.Free carboxylic acids are located on an acetylated saponin by looking at the disappearance, in the presence of Eu complexes, of the carbon situated α to the carbonyl in the (13)C n.m.r. spectrum.The above methods have been employed to determine the structures of the seven major saponins of alfalfa root, which are allegedly responsible for the antifeedant properties of the vegetable.
- Massiot, Georges,Lavaud, Catherine,Men-Olivier, Louisette Le,Binst, Georges Van,Miller, Stephen P. F.,Fales, Henry M.
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p. 3071 - 3080
(2007/10/02)
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- STRUCTURE DE LA ZANHINE ET DE LA MEDICAGINE, DEUX PROSAPOGENINES NOUVELLES ISOLEES DE ZANHA GOLUNGENSIS HIERN
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From the perchloric hydrolysis of the root bark saponin of Zanha golungensis Hiern.We have isolated two novel prosapogenins: 3β-O-(4-deoxy-β-D-hex-4-enopyranosyluronic acid), 2β-hydroxy-olean-12-en-23,28-dioic acid (medicagin) and 3β-O-(4-deoxy-β-D-hex-4-enopyranosyluronic acid), 2β,16α-dihydroxy-olean-12-en-23,28-dioic acid (zanhin).The structures have been established by spectroscopic data.A two-dimensional NMR of Zanhin is described.
- Dimbi, Makoso Zeza,Warin, Roger,Delaude, Clement,Huls, Robert
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p. 207 - 218
(2007/10/02)
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- TRITERPENE GLYCOSIDES OF ALFALFA. I. MEDICOSIDE G - A NEW BISDESMOSIDE FROM Medicago sativa
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A new triterpene glycoside, medicoside G has been isolated from the roots of the plant Medicago sativa L. (family Fabaceae), and its structure has been established as medicagenic acid 3,28-di-O-β-D-glucopyranoside.
- Timbekova, A. E.,Abubakirov, N. K.
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p. 427 - 433
(2007/10/02)
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